DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk1 and SGK3

DIOPT Version :10

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_037389.4 Gene:SGK3 / 23678 HGNCID:10812 Length:496 Species:Homo sapiens


Alignment Length:485 Identity:144/485 - (29%)
Similarity:227/485 - (46%) Gaps:59/485 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KLNLPDPSVRSVMYKYLEKEGELNFHKIFNEV--LGYLLFKDFCENDSEEPIQQLKFFEQI-KLF 92
            |.:.|..|:.| ..::.||:.....:|:...|  ..:.:|:.:.|.|        |.:..: |.|
Human    10 KESCPSVSIPS-SDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFD--------KLYNTLKKQF 65

  Fly    93 EKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQL 157
            .........|::..|.:|...:::..:...|:.::.|...:.|   |...|        ..|.|:
Human    66 PAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELY---NHPDV--------RAFLQM 119

  Fly   158 KGKPFKKFLESDKFTRFCQ-----WKNLEL----NIQLTMNDFSVHRIIGRGGFGEVYGCRKADT 213
            .....:.....|:..|..|     .:|:.|    |......||...::||:|.||:|...::...
Human   120 DSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD 184

  Fly   214 GKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGG 278
            ||.||:|.|.||.:..::.:...:.|||:|   ...:..||:|.:.|:|.|.:||.|:||.:|||
Human   185 GKFYAVKVLQKKIVLNRKEQKHIMAERNVL---LKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246

  Fly   279 DLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF 343
            :|.:||.:...|.|...:|||||:...|.::|...||||||||.|||||..||:.::|.||.   
Human   247 ELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLC--- 308

  Fly   344 SKKKPHASV--------GTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDK 400
               |...::        ||..|:||||:.| ..||:..||:..|.:||::|.|..||   ..:|.
Human   309 ---KEGIAISDTTTTFCGTPEYLAPEVIRK-QPYDNTVDWWCLGAVLYEMLYGLPPF---YCRDV 366

  Fly   401 LEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQ 465
            .|:....|...:.|....||...::||.||::|...|||...:.. |::.|.||..:.|..:..:
Human   367 AEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQK 430

  Fly   466 KYTPPLVPPRGEVNAADAFDIGSFDEEDTK 495
            |..||..|     |.|...||.:||...|:
Human   431 KIPPPFNP-----NVAGPDDIRNFDTAFTE 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 30/166 (18%)
Protein Kinases, catalytic domain 185..531 CDD:473864 114/319 (36%)
PH_GRK2_subgroup 552..675 CDD:269946
SGK3NP_037389.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/11 (36%)
PX_CISK 12..120 CDD:132780 23/127 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..156 6/34 (18%)
STKc_SGK3 165..490 CDD:270755 112/310 (36%)
Nuclear localization signal. /evidence=ECO:0000250 195..205 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

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