DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and grk-1

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_509676.1	Gene:	grk-1 / 181212	WormBaseID:	WBGene00001708	Length:	642	Species:	Caenorhabditis elegans

Alignment Length:	630	Identity:	214/630 - (33%)
Similarity:	322/630 - (51%)	Gaps:	104/630 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLEAVLADVSYLMAME-----KSKCTPAARASKKLN-----------LPDPSVRSVMYKYLEKEG 51
            ::|.::|:..|:.|.|     |.|       |||..           ||..:...|.|.::
Worm     2 EIENIVANTVYIKARESGGQKKGK-------SKKWKNYLQFPHYTECLPLKTEIEVTYAFV---- 55

  Fly    52 ELNFHKIFNEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDE---RKKMARDIY---- 109
                  :..:.:|.|||.:||:..:.:..|..:|..:::.:|.::  |:   |:.:|..|.
Worm    56 ------VEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSD--DDGQSRRDLASSIVSLLH 112

  Fly   110 ----DN-------------FIMEEMLS---HTYEYSKHAVASVQKYLLKNEVPVDLF-EPYLEEI 153
                ||             |:.:|::|   .|.:.:.|          .:|...|:| |||  .:
Worm   113 SKPEDNPSGSQDEQEFWCSFLSDEVISTCITTADSATH----------DDEPRSDIFTEPY--RL 165

  Fly   154 FTQ-LKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY 217
            ..| |...|||:|.||..|.||.|||.||.. .:..:.|.::|::|:||||||..|:...:||||
Worm   166 TCQYLTDAPFKEFAESMYFHRFLQWKWLEKR-PVDKHTFRLYRVLGKGGFGEVCACQVRASGKMY 229

  Fly   218 AMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHY 282
            |:|.|:|||:|.:..|.|:|||:.:||.:::    ||:|.:.||:.|.|.||.:|.|||||||.:
Worm   230 ALKKLEKKRVKKRHAETLSLNEKQILQRINS----PFVVSLAYAYETKDALCLVLTLMNGGDLKF 290

  Fly   283 HL--SQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSK 345
            ||  ...|.|.|..::|||||:.|||:|:|...|:||||||.|||||:.||:||||||||.:...
Worm   291 HLYNLMPGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKD 355

  Fly   346 KKP-HASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKL-EIDKMTL 408
            .:| ...|||.||||||:: |...|....||:..||::|::::|.:||||.|.|.|. |:::...
Worm   356 NEPIKGRVGTVGYMAPEIV-KNERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVR 419

  Fly   409 TMNVELPESFSLELKNLLEMLLQRDVSKRLGC--MG---NGADEVKMHNFFCGID---------W 459
            ....:..|.||...:.|...||.::...||||  :|   :||:|::.|.||...|         |
Worm   420 EDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTADTVTGREPVPW 484

  Fly   460 HQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL-TISERWQQEVS 523
            .::...|.|||..|....|.|.|..||..|  ...||::|:..|...|..|:. .:|..||.|:.
Worm   485 KKMEAGKVTPPFCPDPRAVYAKDVLDIEQF--STVKGVRLDATDTQFYGKFNTGCVSIPWQSEMI 547

  Fly   524 ET-VFDTVNTETDKLEQKRKLKQKQHFDADEKESDCILHGYIKKL 567
            || .|..:||..|:........:....:.||:.:.....|:..:|
Worm   548 ETECFAELNTFHDEDGNVMWNLRPDGINMDERRNGTSKPGFFSRL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	48/195 (25%)
		PKc_like	185..531	CDD:304357	151/365 (41%)
		Pkinase	191..454	CDD:278497	123/271 (45%)
		PH_GRK2_subgroup	552..675	CDD:269946	4/16 (25%)
		PH	559..657	CDD:278594	2/9 (22%)
grk-1	NP_509676.1	RGS	34..196	CDD:295367	46/185 (25%)
		PKc_like	202..500	CDD:304357	132/302 (44%)
		S_TKc	203..470	CDD:214567	123/271 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820