DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and grk-2

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_497235.2	Gene:	grk-2 / 175223	WormBaseID:	WBGene00001709	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	680	Identity:	475/680 - (69%)
Similarity:	557/680 - (81%)	Gaps:	1/680 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            ||||||||||||||||||||:..|||||||::.||||||||:|.|:|||.|::.|.||||:.||:
Worm     1 MADLEAVLADVSYLMAMEKSRSQPAARASKRIVLPDPSVRSIMQKFLEKSGDMKFDKIFNQKLGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            ||.||:.||.||.|..|:||:|.||.:||.|..|||...||:|||:.||.|||:|.:.|||.::.
Worm    66 LLLKDYAENVSESPCPQIKFYEAIKEYEKMETPDERLTKAREIYDHHIMVEMLAHAHNYSKESLQ 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|||..||.|||..|:.||..||:|..|::|||||||||||||||||||:|||||||||||
Worm   131 HVQYHLLKQNVPPDLFHRYVLEICDQLRGDIFQRFLESDKFTRFCQWKNLELNMQLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..||||.||||||||||
Worm   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTY 260

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||.:||||||||||||||||||||||||:|:|.||.|||:||||||||||.|.:|||||||||||
Worm   261 AFQSPDKLCFILDLMNGGDLHYHLSQHGVFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANIL 325

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            ||||||:|:||||||||:||||||||||||||||||||:||.:|||.|||||.||||||||||||
Worm   326 LDENGHVRVSDLGLACDYSKKKPHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHS 390

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELP-ESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF 454
            ||||||:|||.||||||||.::||| |..|.:.::|||.||:|||..||||.|.|..|||.|.||
Worm   391 PFRQHKSKDKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF 455

  Fly   455 CGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQ 519
            ..:||..||:::.||||:|||||||||||||||:||:::.||:||.|.|.||||.|::.||||||
Worm   456 KDVDWQTVYLRRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNIVISERWQ 520

  Fly   520 QEVSETVFDTVNTETDKLEQKRKLKQKQHFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLYP 584
            .|::||:|:.||.:.||.|.|::.|||.....:||:||.|:|||||||||.|.|.|||||.||||
Worm   521 NEIAETIFEVVNQDADKAESKKRSKQKIKVAVEEKDSDVIVHGYIKKLGGPFTSAWQTKYGKLYP 585

  Fly   585 NRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEWS 649
            :||||:.||...||||:||||:||:.::....|.|..|.:::.||.::.:|.|||||||.||||.
Worm   586 SRLELYPESLTAKPELVFMDQIEDVCAEMQTIKGETAIIVKLRDGFKEPKICLTNSDEISLKEWH 650

  Fly   650 SSLRSAHKISQDLLGSMAKKAGKIYGSERD 679
            :|||:|||:||:||..|.:||.||||...|
Worm   651 TSLRTAHKVSQELLQRMGRKAIKIYGVNHD 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	93/155 (60%)
		PKc_like	185..531	CDD:304357	271/346 (78%)
		Pkinase	191..454	CDD:278497	217/263 (83%)
		PH_GRK2_subgroup	552..675	CDD:269946	73/122 (60%)
		PH	559..657	CDD:278594	58/97 (60%)
grk-2	NP_497235.2	RGS_GRK2_GRK3	30..186	CDD:188701	93/155 (60%)
		Pkinase	191..455	CDD:278497	217/263 (83%)
		STKc_beta_ARK	196..475	CDD:270757	222/278 (80%)
		S_TK_X	456..530	CDD:214529	46/73 (63%)
		PH_GRK2_subgroup	553..676	CDD:269946	73/122 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167269
Domainoid	1	1.000	455	1.000	Domainoid score	I252
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21072
Inparanoid	1	1.050	982	1.000	Inparanoid score	I149
Isobase	1	0.950	-	0	Normalized mean entropy	S1090
OMA	1	1.010	-	-		QHG45729
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		oto20103
orthoMCL	1	0.900	-	-		OOG6_106250
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2554
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750