DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gprk1 and GRK3

DIOPT Version :9

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_005151.2 Gene:GRK3 / 157 HGNCID:290 Length:688 Species:Homo sapiens


Alignment Length:680 Identity:454/680 - (66%)
Similarity:536/680 - (78%) Gaps:13/680 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.||||||||::.||:||:||||.|||.:..|:.|.||||:.:|:
Human     1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|...:|.|||.:||:|:||.::.:||.||.
Human    66 LLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:|||||||||||||:||||.||||:|||||
Human   131 HVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||||
Human   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||||||||||||||||||||||:|||.||:|||.|:||||||||.|.:|||||||||||
Human   260 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||.|||||||||||||||||||||||||||||||.|||:|||.|||||.||||:|||:|||
Human   325 LDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||:|||||::||.|||:|||.||||||||||||.|.|:.|||.|:||.
Human   390 PFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            |:||..||:|||.|||:|||||||||||||||||||||||||||.|.||:|||.|.|.|||||||
Human   455 GVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:|||::.||.:|||:|.:::.|.||  |.:......|||:|||:.|||..|.:.||.:|..|:
Human   520 EVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |::.||..||..|.   :.:|....:....:|
Human   585 PNRLEWRGE-GESRQNLLTMEQILSVEETQI--KDKKCILFRIKGGK---QFVLQCESDPEFVQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            ...|....|.:|.||    ::|.|.....|
Human   644 KKELNETFKEAQRLL----RRAPKFLNKPR 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 84/155 (54%)
PKc_like 185..531 CDD:304357 291/345 (84%)
Pkinase 191..454 CDD:278497 227/262 (87%)
PH_GRK2_subgroup 552..675 CDD:269946 40/122 (33%)
PH 559..657 CDD:278594 32/97 (33%)
GRK3NP_005151.2 N-terminal 1..190 115/188 (61%)
RGS_GRK2_GRK3 30..186 CDD:188701 84/155 (54%)
STKc_GRK3 185..530 CDD:270781 291/345 (84%)
PH_GRK2_subgroup 553..670 CDD:269946 41/127 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 669..688 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 476 1.000 Domainoid score I439
eggNOG 1 0.900 - - E1_KOG0986
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21072
Inparanoid 1 1.050 915 1.000 Inparanoid score I362
Isobase 1 0.950 - 0 Normalized mean entropy S1090
OMA 1 1.010 - - QHG45729
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 1 1.000 - - FOG0004399
OrthoInspector 1 1.000 - - otm40682
orthoMCL 1 0.900 - - OOG6_106250
Panther 1 1.100 - - LDO PTHR24355
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2554
SonicParanoid 1 1.000 - - X3114
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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