Protein Alignment Gprk1 and GRK3

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_005151.2
• Gene: GRK3 / 157
• HGNCID: 290
• Length: 688
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 454/680 - (66%)
• Similarity: 536/680 - (78%)
• Gaps: 13/680 - (1%)

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.||||||||::.||:||:||||.|||.:..|:.|.||||:.:|:
Human     1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|...:|.|||.:||:|:||.::.:||.||.
Human    66 LLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:|||||||||||||:||||.||||:|||||
Human   131 HVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||||
Human   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||||||||||||||||||||||:|||.||:|||.|:||||||||.|.:|||||||||||
Human   260 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||.|||||||||||||||||||||||||||||||.|||:|||.|||||.||||:|||:|||
Human   325 LDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||:|||||::||.|||:|||.||||||||||||.|.|:.|||.|:||.
Human   390 PFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            |:||..||:|||.|||:|||||||||||||||||||||||||||.|.||:|||.|.|.|||||||
Human   455 GVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:|||::.||.:|||:|.:::.|.||  |.:......|||:|||:.|||..|.:.||.:|..|:
Human   520 EVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |::.||..||..|.   :.:|....:....:|
Human   585 PNRLEWRGE-GESRQNLLTMEQILSVEETQI--KDKKCILFRIKGGK---QFVLQCESDPEFVQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            ...|....|.:|.||    ::|.|.....|
Human   644 KKELNETFKEAQRLL----RRAPKFLNKPR 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	84/155 (54%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	291/345 (84%)
		PH_GRK2_subgroup	552..675	CDD:269946	40/122 (33%)
GRK3	NP_005151.2	N-terminal	1..190		115/188 (61%)
		RGS_GRK2_GRK3	30..186	CDD:188701	84/155 (54%)
		STKc_GRK3	185..530	CDD:270781	291/345 (84%)
		PH_GRK2_subgroup	553..670	CDD:269946	41/127 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	669..688		1/1 (100%)