Protein Alignment Gprk1 and Grk4

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_062370.2
• Gene: Grk4 / 14772
• MGIID: 95801
• Length: 574
• Species: Mus musculus
• Alignment Length: 542
• Identity: 198/542 - (36%)
• Similarity: 300/542 - (55%)
• Gaps: 38/542 - (7%)

  Fly    29 SKK----LNLPDPSVRSVMYKYLEKEGELNFHKIFN-EVLGYLLFKDFCENDSEEPIQQ-LKFFE 87
            |||    |..|..|:.:.:...:||:    |..:.: :.:|.|||:.||  |::..::: ::|.:
Mouse    26 SKKWRELLKFPPVSMCTELRWSIEKD----FSSLCDKQPIGRLLFRQFC--DTKPDLKRCIEFLD 84

  Fly    88 QIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEE 152
            .:..:|.| ..:|:::....|:..|..|:......|.....|...:..|.:|....::||.....
Mouse    85 AVAEYEVT-IEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGI 148

  Fly   153 IFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY 217
            :...|...||:::.||..|.||.|||.||.. .:|.|.|..:|::|:||||||..|:...|||||
Mouse   149 VCKYLSETPFEEYQESTYFNRFLQWKWLERR-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212

  Fly   218 AMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHY 282
            |.|.|:|||||.::||.:||||:.:|:.:.:    .|:|.:.|.:.|.|.||.:|.:||||||.|
Mouse   213 ACKKLEKKRIKKRKGEAMALNEKRILEKLHS----RFVVSLAYTYETKDALCLVLTIMNGGDLKY 273

  Fly   283 HLSQHGI--FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSK 345
            |:...|.  |.|....|||||:..|||.:.::.||||||||.|||||::|||||||||||.:..:
Mouse   274 HIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPE 338

  Fly   346 -KKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTL 408
             :.....|||.||||||:::. ..|....||:..||::|:::.||||||::|.| ::.|:::...
Mouse   339 GEMVRGRVGTVGYMAPEIINH-EKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVK 402

  Fly   409 TMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVP 473
            ....|..|.||.:.|::..|||.:|.||||||..:|...||.|..|..|::.::......||.:|
Mouse   403 NETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIP 467

  Fly   474 PRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMF---SLTISERWQQEVSET-VFDTVNTET 534
            ....:...:..|||.|..  .||:.|:..|:..|..|   |:||.  ||.|:.|: .|..:|...
Mouse   468 DPQAIYCRNILDIGQFSV--VKGVNLDTNDEIFYAEFATGSVTIP--WQNEMIESGCFKDLNENE 528

  Fly   535 DKLEQKRK-------LKQKQHF 549
            |.|....|       |:.|::|
Mouse   529 DDLSSLEKYKMCSSILRPKRNF 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	41/161 (25%)
		PKc_like	185..531	CDD:304357	149/353 (42%)
		Pkinase	191..454	CDD:278497	124/266 (47%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Grk4	NP_062370.2	N-terminal	1..153		29/133 (22%)
		RGS	51..183	CDD:295367	34/139 (24%)
		STKc_GRK4_like	185..469	CDD:270756	129/288 (45%)
		S_TKc	186..448	CDD:214567	124/266 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810