Protein Alignment Gprk1 and Gprk1

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_061516725.1
• Gene: Gprk1 / 1280643
• VectorBaseID: AGAMI1_009833
• Length: 728
• Species: Anopheles gambiae
• Alignment Length: 713
• Identity: 578/713 - (81%)
• Similarity: 635/713 - (89%)
• Gaps: 15/713 - (2%)

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            ||||||||||||||||||||||.||||||||:.||||||||||:||||||.|:||.||||:||||
Mosquito     1 MADLEAVLADVSYLMAMEKSKCMPAARASKKIVLPDPSVRSVMHKYLEKENEVNFDKIFNQVLGY 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||:|||:|.||||:..|||:|:||.:|||||:|||:|.|||||||:||:||||||:||||.|||
Mosquito    66 LLFRDFCDNVSEEPVPHLKFYEEIKAYEKTECHDERRKQARDIYDNYIMKEMLSHTHEYSKEAVA 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .|||||:||||||:|||||:||||..|:|:||:|||||||:||||||||||||||||||||||||
Mosquito   131 HVQKYLMKNEVPVNLFEPYIEEIFHHLRGEPFRKFLESDKYTRFCQWKNLELNIQLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..||||:||||||||||
Mosquito   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERTMLSLVSTGVDCPFIVCMTY 260

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||||||||||||||||||||||:|:|.:||||||||||||||||||.||||||||||||
Mosquito   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFNESDMKFYAAEVILGLEHMHKRFIVYRDLKPANIL 325

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            ||||||:|||||||||||||||||||||||||||||||||||.|||.||||||||||||||||||
Mosquito   326 LDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTPYDSSADWFSFGCMLYKLLKGHS 390

  Fly   391 PFRQHKTKDKLEIDKMTLTM------NVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVK 449
            ||||||||||.|||:|||||      |||||||||.||::|||.|||||:.|||||.|.||:|||
Mosquito   391 PFRQHKTKDKHEIDRMTLTMQPSPLQNVELPESFSKELRDLLEGLLQRDIDKRLGCKGGGAEEVK 455

  Fly   450 MHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTI 514
            .|.||.||||:|||.|||||||:|||||||||||||||||||||||||||.:.||:||:.|.|||
Mosquito   456 CHPFFAGIDWNQVYYQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTEQDQELYRYFPLTI 520

  Fly   515 SERWQQEVSETVFDTVNTETDKLEQKRKLKQKQHFDADEKESDCILHGYIKKLGGSFASLWQTKY 579
            ||||||||:||||:|||||.||||||||.||||.||||||||||||||||||.||||||:|||:|
Mosquito   521 SERWQQEVAETVFETVNTEADKLEQKRKAKQKQRFDADEKESDCILHGYIKKYGGSFASVWQTRY 585

  Fly   580 AKLYPNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIG 644
            |||||||||||:|||:.||||:||||:|::|.||:..|||.|:|:|..||.|||::|||||||||
Mosquito   586 AKLYPNRLELHTESGSTKPELVFMDQIEEVSPDFVQFKNEQCVQVRFRDGIRDGKLILTNSDEIG 650

  Fly   645 LKEWSSSLRSAHKISQDLLGSMAKKAGKIYGSERD---------VNKSMYIFGGNCSTKTSNG 698
            ||||:.|||:|||.||:||||||||||||||:|..         ....|.:.||...|.|..|
Mosquito   651 LKEWALSLRAAHKESQELLGSMAKKAGKIYGTEGQRGAPDARQLAGSGMVLPGGGGGTATGGG 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	121/155 (78%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	306/351 (87%)
		PH_GRK2_subgroup	552..675	CDD:269946	95/122 (78%)
Gprk1	XP_061516725.1	None