Protein Alignment Gprk1 and Gprk2

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_061497034.1
• Gene: Gprk2 / 1273941
• VectorBaseID: AGAMI1_014223
• Length: 651
• Species: Anopheles gambiae
• Alignment Length: 598
• Identity: 197/598 - (32%)
• Similarity: 297/598 - (49%)
• Gaps: 94/598 - (15%)

  Fly     3 DLEAVLADVSYLMAMEKSKCTPAARASK-KLNLPDPSVR---------SVMYKYLEKEGELNFHK 57
            :||.::|:..||.|.|....:...::.| :..|..|.:.         .|.|.|:
Mosquito     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIDLKNKIDVSYGYV---------- 56

  Fly    58 IFNEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFI--------- 113
            :..:.:|..||:.||:....:..:.:.|.:....:| ....:.|..:|.::...::
Mosquito    57 VDQQPIGRELFRQFCKVKRPQYSRYITFLDDATRYE-IAADEHRVDLAFEVAKRYLGLCTESQRE 120

  Fly   114 ------------------------MEEMLSH-TYEYSKHAVASVQKYLLKNEV------------ 141
                                    .:::.:| ..|.|.....||....:.||.
Mosquito   121 DSGGGGGCDSDGGKCDDDSGIGGDTKKLSNHDDPEKSLTGSNSVTTNTINNEKDEFVLDVLNDDM 185

  Fly   142 -----------PVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
                       ..:|||..:..:...|.|:||::|..|..|.|:.|||.||.. .:|...|.::|
Mosquito   186 VGQIRTKLSTGSKELFEASITAVRAFLAGEPFREFEASMYFHRYLQWKWLEAQ-PVTYKTFRMYR 249

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ::|:||||||..|:...||||||.|.|:|||||.::||.:.|.|:.:||.:::    .|:|.:.|
Mosquito   250 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS----RFVVNLAY 310

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHG---IFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPA 322
            |:.|.|.||.:|.:||||||.:|:...|   .|.....:||||||:.||||:|::.|||||.||.
Mosquito   311 AYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELSRARFYAAEVVCGLEHLHQQGIVYRDCKPE 375

  Fly   323 NILLDENGHIRISDLGLACDFSK-KKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLL 386
            |||||::||:||||||||.:..: :.....|||.|||||||:. ...|....|||||||:||:::
Mosquito   376 NILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYSFSPDWFSFGCLLYEMI 439

  Fly   387 KGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMG--NGADEV 448
            :|.:|||..|.|.|. |:|:.......:....||.:.|:|.:.||.:.|..||||..  :||.||
Mosquito   440 EGQAPFRARKEKVKREEVDRRVKEDAEKYSHKFSDDAKSLCQQLLVKAVKSRLGCRNGRHGAREV 504

  Fly   449 KMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL- 512
            |::.||..|:|.::......||.||....|.|.|..||..|  ...||:.|:..|::.|..|:.
Mosquito   505 KLNPFFNSINWKRLEAGLNDPPFVPDPHAVYAKDVLDIEQF--STVKGVNLDATDENFYTKFNTG 567

  Fly   513 TISERWQQEVSET 525
            ::|..||.|:.||
Mosquito   568 SVSIPWQDEMIET 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	38/222 (17%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	152/349 (44%)
		PH_GRK2_subgroup	552..675	CDD:269946
Gprk2	XP_061497034.1	None