DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gprk1 and Grk2

DIOPT Version :9

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_001277747.1 Gene:Grk2 / 110355 MGIID:87940 Length:689 Species:Mus musculus


Alignment Length:674 Identity:450/674 - (66%)
Similarity:540/674 - (80%) Gaps:9/674 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.|||||||||:.||:||:||||.||||..||:.|.|||::.|||
Mouse     1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGY 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||:|||.|..||....::|:|:||.:||.|..:||...:|:|:|::||:|:|:.::.:||:|..
Mouse    66 LLFRDFCLNHLEEAKPLVEFYEEIKKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|:|.:||.|||:||:|||...|:|..|:||:|||||||||||||:||||.||||||||||
Mouse   131 HVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||:|
Mouse   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||.|||||||||||||||||||:|||.:|:|||||:||||||||.|.:|||||||||||
Mouse   260 AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||:||||||||||||||:||||||||||||||||.||.:|||.|||||.||||:|||:|||
Mouse   325 LDEHGHVRISDLGLACDFSKKRPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:|||||.||||:|||.||::|||.||||||::||||:|.||.|||...||.
Mouse   390 PFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            .:||..|::|||.|||:|||||||||||||||||||||||||||.|:||:||:.|.|||||||||
Mouse   455 SLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:||||||:|.|||:||.::|.|.||  |.:......|||:|||:.|:|..|.:.||.:|..|:
Mouse   520 EVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIVHGYMSKMGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.....|:.|::::.:....|  |...|:.::|..|.   :.:|....:..|.:|
Mouse   585 PNRLEWRGE-GEAPQSLLTMEEIQSVEETQI--KERKCLLLKIRGGK---QFVLQCDSDPELVQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGK 672
            ...||.|::.:|.|:..:.|...|
Mouse   644 KKELRDAYREAQQLVQRVPKMKNK 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 87/155 (56%)
PKc_like 185..531 CDD:304357 287/345 (83%)
Pkinase 191..454 CDD:278497 221/262 (84%)
PH_GRK2_subgroup 552..675 CDD:269946 37/121 (31%)
PH 559..657 CDD:278594 31/97 (32%)
Grk2NP_001277747.1 N-terminal 1..190 118/188 (63%)
RGS_GRK2_GRK3 30..186 CDD:188701 87/155 (56%)
STKc_GRK2 190..510 CDD:271125 265/320 (83%)
Pkinase 191..453 CDD:278497 221/262 (84%)
PH_GRK2_subgroup 553..670 CDD:269946 37/121 (31%)
PH 562..650 CDD:278594 29/93 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845430
Domainoid 1 1.000 465 1.000 Domainoid score I468
eggNOG 1 0.900 - - E1_KOG0986
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 915 1.000 Inparanoid score I362
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45729
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 1 1.000 - - FOG0004399
OrthoInspector 1 1.000 - - otm42755
orthoMCL 1 0.900 - - OOG6_106250
Panther 1 1.100 - - O PTHR24355
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2554
SonicParanoid 1 1.000 - - X3114
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.800

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