Protein Alignment Gprk1 and grk1

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_002937018.3
• Gene: grk1 / 100486335
• XenbaseID: XB-GENE-1012638
• Length: 559
• Species: Xenopus tropicalis
• Alignment Length: 563
• Identity: 198/563 - (35%)
• Similarity: 303/563 - (53%)
• Gaps: 49/563 - (8%)

  Fly     4 LEAVLADVSYLMAMEK--SKCTPAARASKK----LNLPDPSVRSVMYKYLEKEGELNFHKI-FNE 61
            ||.|:|:.:|:.|...  ....|....:||    |.||..|    ..::|:.:.:|.|..| ..:
 Frog     6 LETVVANSAYITARGSFDGGFNPQITRNKKYRARLKLPPLS----ECEHLKDKLDLQFENICVKQ 66

  Fly    62 VLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYD-----ERKKMARDIYDNFIMEEMLSHT 121
            .:|..||::|.|:        .:|...::::...|.||     :|...||.|.:.::..:.....
 Frog    67 PIGKKLFQEFLES--------AEFTHIVEIWNDIEDYDVAEDEDRLYKARGIINKYLDSDSKQFC 123

  Fly   122 YEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQL 186
            :...:.|:..|.:..  |:|...||:...:.....||...|.::.||..|::|.|||.||  .|.
 Frog   124 HYLDEKAIIKVVQDC--NKVSNMLFKQLHKSTLDYLKENAFAQYKESKYFSKFLQWKKLE--AQP 184

  Fly   187 TMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGI 250
            ..:| |...||:|:||||||...:...||||||.|.|.|||:|.::|...|:.|:.:|..|.:
 Frog   185 IGDDWFMDFRILGKGGFGEVSATQMRATGKMYACKKLSKKRLKKRKGFEGAMVEKRILAKVHS-- 247

  Fly   251 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL-----SQHGIFSEDEMKFYAAEVILGLEHMH 310
              .|||.:.|||.|.:.:|.::.:||||||.:|:     ...|| .|....||.|::|.||||:|
 Frog   248 --RFIVSLAYAFQTKNDVCLVMTIMNGGDLRFHIYNMDEENPGI-DEHRASFYTAQIISGLEHLH 309

  Fly   311 KRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLSKGTSYDSCA 373
            :..|:||||||.|:|||.:|::||||||||.:..:||..|.  .||.|:||||:| :|..||...
 Frog   310 QNRIIYRDLKPENVLLDNDGNVRISDLGLAVELKEKKSKAKGYAGTPGFMAPELL-QGEEYDYAV 373

  Fly   374 DWFSFGCMLYKLLKGHSPF--RQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSK 436
            |:||.|..||:::....||  |..|.::| |:....|..:|.....|||:.|::.|.||.:|..|
 Frog   374 DYFSLGVTLYEMIAARGPFRCRGEKVENK-ELKNRILNDSVTYSGKFSLDCKSICEALLDKDPKK 437

  Fly   437 RLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLND 501
            |:|......:|:::|.||.||:|.::......||..|....|.|.|..|:|:|  ...||:.|::
 Frog   438 RMGFKNGNCNEIRVHLFFRGINWRKLEAGILPPPFAPDSRIVYAKDIQDVGAF--STVKGVTLDE 500

  Fly   502 ADQDLYKMF-SLTISERWQQEVSET-VFDTVNTETDKLEQKRK 542
            :|..|:..| |..||..||:|:.|| :||.:|:|.::...:|:
 Frog   501 SDNKLFDEFASGNISIPWQEEMVETGIFDEINSELNENNVRRE 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	41/165 (25%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	147/357 (41%)
		PH_GRK2_subgroup	552..675	CDD:269946
grk1	XP_002937018.3	RGS_GRK1	43..178	CDD:188702	33/148 (22%)
		STKc_GRK1	188..475	CDD:270759	123/293 (42%)