DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and grk3

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_002932117.2	Gene:	grk3 / 100379889	XenbaseID:	XB-GENE-6043587	Length:	688	Species:	Xenopus tropicalis

Alignment Length:	700	Identity:	472/700 - (67%)
Similarity:	555/700 - (79%)	Gaps:	15/700 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.|||||||||:.||:||:||||.||||:.|||.|.||||:.:|:
Frog     1 MADLEAVLADVSYLMAMEKSKSTPAARASKKIVLPEPSIRSVMQKYLEERGELTFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.||.:|.:.||||:|:||.:||.:..::|...:|.|||.:||:|:||.::.:||.||.
Frog    66 LLFKDFCMNDMDEGVPQLKFYEEIKEYEKLDSEEDRLCRSRQIYDTYIMKELLSCSHPFSKQAVD 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:||..||:||:|||...|:||.|::|:|||:|||||||||:||||.||||||||||
Frog   131 HVQAHLAKKQVPPTLFQPYIEEICDSLRGKIFQRFIESDRFTRFCQWKNVELNIHLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||||
Frog   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||||||||||||||||||||||:|||.||:|||||:||||||||.|.:|||||||||||
Frog   260 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYAAEIILGLEHMHHRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||:|||||||||||||||||||||||||||||||.|||:|||.|||||.||||:|||:|||
Frog   325 LDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||||||||:|||.|||:|||.||||||||||||.|.||.|||.|.||.
Frog   390 PFRQHKTKDKHEIDRMTLTMNVELPDSFSPELKSLLEGLLQRDVSKRLGCQGGGAQEVKEHAFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            ||||.|||:|||.|||:|||||||||||||||||||||||||||.|:||:|||.|.|.|||||||
Frog   455 GIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:|||::.||.:|||:|.:::.|.||  |.:......|||:|||:.|||..|.:.||.:|..|:
Frog   520 EVAETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |::.||.:||. |.:  :.:|....:....:|
Frog   585 PNRLEWRGE-GESRQNLLTMEQIVSVEDTQI--KDKKCILLRIK-GAK--QFVLQCESDPEFVQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSERDVNKSMYIFGGNCSTKTSNG 698
            ...|..|...:|.||    ::|.|...:.|  :..:.|.....|.:.|||
Frog   644 KKELTEAFTEAQRLL----RRAPKFLNNPR--SAVVEIAKPPLSHRNSNG 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	90/155 (58%)
		PKc_like	185..531	CDD:304357	298/345 (86%)
		Pkinase	191..454	CDD:278497	231/262 (88%)
		PH_GRK2_subgroup	552..675	CDD:269946	40/122 (33%)
		PH	559..657	CDD:278594	33/97 (34%)
grk3	XP_002932117.2	RGS_GRK2_GRK3	30..186	CDD:188701	90/155 (58%)
		STKc_GRK3	185..530	CDD:270781	298/345 (86%)
		PH_GRK2_subgroup	553..670	CDD:269946	41/128 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21072
Inparanoid	1	1.050	929	1.000	Inparanoid score	I351
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		oto102832
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060