DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17683 and NAR1

DIOPT Version :9

Sequence 1:	NP_001036428.1	Gene:	CG17683 / 3355011	FlyBaseID:	FBgn0262115	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_014159.1	Gene:	NAR1 / 855481	SGDID:	S000005184	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	487	Identity:	147/487 - (30%)
Similarity:	232/487 - (47%)	Gaps:	98/487 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSRALQLTDIDDFITPSQICIKPVQIDKARSKTGAKIKIKGDGCFEESESGNLKLNKVDISLQDC 68
            :|..|..:|::|||:|:..|:||.|:     ..|.|..:..:|.:|.|...: :|.||.|:|.||
Yeast     1 MSALLSESDLNDFISPALACVKPTQV-----SGGKKDNVNMNGEYEVSTEPD-QLEKVSITLSDC 59

  Fly    69 LACSGCITSAEEVLITQQSREELLKVLQENSKNKASEDWDNVRTIVFTLATQPILSLAYRYQIGV 133
            |||||||||:||:|::.||....||     :..|.|:..|  :.:|.:::.|..||||..|.:.:
Yeast    60 LACSGCITSSEEILLSSQSHSVFLK-----NWGKLSQQQD--KFLVVSVSPQCRLSLAQYYGLTL 117

  Fly   134 EDAARHLNGYF-RSLGADYVLSTKVADDIALLECRQEFVDRYRENENL-----TMLSSSCPGWVC 192
            |.|...|..:| :.....|::.|::...|::.:..::.:...::.||.     .:||:.|||::.
Yeast   118 EAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKIIAHKKQKENTGADRKPLLSAVCPGFLI 182

  Fly   193 YAEKTHGNFLLPYVSTTRSPQQIMGVLVKQILADKMNVPASRIYHVTVMPCYDKKLEASREDFFS 257
            |.|||... |:|.:...:|||||.|.|::... :.:.:.....||:::|||:||||||||.:...
Yeast   183 YTEKTKPQ-LVPMLLNVKSPQQITGSLIRATF-ESLAIARESFYHLSLMPCFDKKLEASRPESLD 245

  Fly   258 KANNSRDVDCVITSVEVEQLLSEAQQPLSQYDLLDLDWP---------WSNVRP----EFMVWAH 309
            ..     :|||||..|:..:|.|          |:||:.         :..:.|    ..:.||.
Yeast   246 DG-----IDCVITPREIVTMLQE----------LNLDFKSFLTEDTSLYGRLSPPGWDPRVHWAS 295

  Fly   310 E-KTLSGGYAEHIFKY--AAKHIFNEDLKTELEFKQLKNRDFREIILKQNGKTVLKFAIANGFRN 371
            . ....||||   ::|  |.:.:........||.   :|.|..|..|..:.:.:...:..:||||
Yeast   296 NLGGTCGGYA---YQYVTAVQRLHPGSQMIVLEG---RNSDIVEYRLLHDDRIIAAASELSGFRN 354

  Fly   372 IQNLVQKL-------------------------KREKVS-------NYH--FVEVMACPSGCING 402
            |||||:||                         .||..:       .||  ::||.|||..|:||
Yeast   355 IQNLVRKLTSGSGSERKRNITALRKRRTGPKANSREMAAATAATADPYHSDYIEVNACPGACMNG 419

  Fly   403 GAQIRPTTGQHVRELTRKLEELYQNLPRSEPE 434
            |..:   .|:. ..|.||  :|.|.|.:...|
Yeast   420 GGLL---NGEQ-NSLKRK--QLVQTLNKRHGE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17683	NP_001036428.1	Nar1	29..464	CDD:226972	136/462 (29%)
		Fe_hyd_lg_C	111..406	CDD:280978	97/350 (28%)
		Fe_hyd_SSU	419..465	CDD:214899	6/16 (38%)
NAR1	NP_014159.1	Nar1	21..484	CDD:226972	139/467 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341779
Domainoid	1	1.000	106	1.000	Domainoid score	I1452
eggNOG	1	0.900	-	-		E1_COG4624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1014
Isobase	1	0.950	-	0	Normalized mean entropy	S1691
OMA	1	1.010	-	-		QHG54208
OrthoFinder	1	1.000	-	-		FOG0002027
OrthoInspector	1	1.000	-	-		oto100022
orthoMCL	1	0.900	-	-		OOG6_101268
Panther	1	1.100	-	-	LDO	PTHR11615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R794
SonicParanoid	1	1.000	-	-		X1333
TreeFam	1	0.960	-	-
	15	14.740