DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17683 and CIAO3

DIOPT Version :9

Sequence 1:	NP_001036428.1	Gene:	CG17683 / 3355011	FlyBaseID:	FBgn0262115	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_071938.1	Gene:	CIAO3 / 64428	HGNCID:	14179	Length:	476	Species:	Homo sapiens

Alignment Length:	487	Identity:	230/487 - (47%)
Similarity:	316/487 - (64%)	Gaps:	24/487 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRLSRALQLTDIDDFITPSQICIKPVQIDKARSKTGAKIKIKGDGCFEE--SESGNLKLNKVDIS 64
            |..|.||||||:||||.|||.|||||:::|......|||:|:.||.:.:  .:.|..:|.|..:|
Human     3 SPFSGALQLTDLDDFIGPSQECIKPVKVEKRAGSGVAKIRIEDDGSYFQINQDGGTRRLEKAKVS 67

  Fly    65 LQDCLACSGCITSAEEVLITQQSREELLKVLQENSKNKASEDWDNVRTIVFTLATQPILSLAYRY 129
            |.|||||||||||||.|||||||.|||.|||..|.....|:.    |.:|.:::.|...|||.|:
Human    68 LNDCLACSGCITSAETVLITQQSHEELKKVLDANKMAAPSQQ----RLVVVSVSPQSRASLAARF 128

  Fly   130 QIGVEDAARHLNGYFRSLGADYVLSTKVADDIALLECRQEFVDRYRE----NENLTMLSSSCPGW 190
            |:...|.||.|..:|:.:|..:|..|..:...:|||.::|||.|:|.    .:.|.:|:|:||||
Human   129 QLNPTDTARKLTSFFKKIGVHFVFDTAFSRHFSLLESQREFVRRFRGQADCRQALPLLASACPGW 193

  Fly   191 VCYAEKTHGNFLLPYVSTTRSPQQIMGVLVKQILADKMNVPASRIYHVTVMPCYDKKLEASREDF 255
            :||||||||:|:||::||.|||||:||.|||...|.:.::...:||||||||||||||||||.||
Human   194 ICYAEKTHGSFILPHISTARSPQQVMGSLVKDFFAQQQHLTPDKIYHVTVMPCYDKKLEASRPDF 258

  Fly   256 FSKANNSRDVDCVITSVEVEQLLSEAQQPLSQYDLLDLDWPWSNVRPEFMVWAHEKTLSGGYAEH 320
            |::.:.:||||||:|:.||.:||.|....|...:...||...|....|... :|....||||.||
Human   259 FNQEHQTRDVDCVLTTGEVFRLLEEEGVSLPDLEPAPLDSLCSGASAEEPT-SHRGGGSGGYLEH 322

  Fly   321 IFKYAAKHIFNEDLKTELEFKQLKNRDFREIILKQNGKTVLKFAIANGFRNIQNLVQKLKREKVS 385
            :|::||:.:|...: .|:.:|.|:|:||:|:.|::.|:.:|.||:|.||||||||||:|||.:..
Human   323 VFRHAARELFGIHV-AEVTYKPLRNKDFQEVTLEKEGQVLLHFAMAYGFRNIQNLVQRLKRGRCP 386

  Fly   386 NYHFVEVMACPSGCINGGAQI----RPTTGQHVRELTRKLEELYQNLPRSEPENSL-TKHIYNDF 445
             ||:||||||||||:|||.|:    ||:     |||.:.:|.||..:....||::. .:.:|..:
Human   387 -YHYVEVMACPSGCLNGGGQLQAPDRPS-----RELLQHVERLYGMVRAEAPEDAPGVQELYTHW 445

  Fly   446 LDGFQSDKSYDVLHTRYHDVVSELSISLNINW 477
            |.|..|:.:..:|||:|| .|.:.|..|.|.|
Human   446 LQGTDSECAGRLLHTQYH-AVEKASTGLGIRW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17683	NP_001036428.1	Nar1	29..464	CDD:226972	204/445 (46%)
		Fe_hyd_lg_C	111..406	CDD:280978	145/298 (49%)
		Fe_hyd_SSU	419..465	CDD:214899	14/46 (30%)
CIAO3	NP_071938.1	Fe_hyd_lg_C	112..403	CDD:308517	142/293 (48%)
CIAO3	NP_071938.1	Fe_hyd_SSU	418..466	CDD:214899	14/48 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142476
Domainoid	1	1.000	285	1.000	Domainoid score	I1623
eggNOG	1	0.900	-	-		E1_COG4624
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6750
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1810
Isobase	1	0.950	-	0	Normalized mean entropy	S1691
OMA	1	1.010	-	-		QHG54208
OrthoDB	1	1.010	-	-		D370258at33208
OrthoFinder	1	1.000	-	-		FOG0002027
OrthoInspector	1	1.000	-	-		otm41834
orthoMCL	1	0.900	-	-		OOG6_101268
Panther	1	1.100	-	-	LDO	PTHR11615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R794
SonicParanoid	1	1.000	-	-		X1333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750