DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17683 and SPCC1450.10c

DIOPT Version :9

Sequence 1:	NP_001036428.1	Gene:	CG17683 / 3355011	FlyBaseID:	FBgn0262115	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_588309.1	Gene:	SPCC1450.10c / 2538783	PomBaseID:	SPCC1450.10c	Length:	538	Species:	Schizosaccharomyces pombe

Alignment Length:	552	Identity:	179/552 - (32%)
Similarity:	271/552 - (49%)	Gaps:	109/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRLSRALQLTDIDDFITPSQICIKPVQIDKARSKTGAKIKIKGDGCFE-ESESGNL-KLNKVDI 63
            |::||    :.|::||::|..:||||.|:.|..||.  .|:|.||..:| ..::|.. :|....|
pombe     1 MAKLS----VNDLNDFLSPGAVCIKPAQVKKQESKN--DIRIDGDAYYEVTKDTGETSELGIASI 59

  Fly    64 SLQDCLACSGCITSAEEVLITQQSREELLKVLQENSKNKASEDWDNVRTIVFTLATQPILSLAYR 128
            ||.|||||||||||||.||:..||.:|:||.|:   ..|:.|      .:..:|:.|...:||..
pombe    60 SLNDCLACSGCITSAETVLVNLQSYQEVLKHLE---SRKSQE------ILYVSLSPQVRANLAAY 115

  Fly   129 YQIGVEDAARHLNGYF-RSLGADYVLSTKVADDIALLECRQEFVDRYRE---------------- 176
            |.:.:::....|...| ..||...:|.|..:.:|.|.:|.|||.:.:.:
pombe   116 YGLSLQEIQAVLEMVFIGKLGFHAILDTNASREIVLQQCAQEFCNSWLQSRAHKNQNQVTNSVVN 180

  Fly   177 -------------------------NEN--LTMLSSSCPGWVCYAEKTHGNFLLPYVSTTRSPQQ 214
                                     |||  |.:||||||||:||.||||.| |:|.:|..|||||
pombe   181 EHPLIPHSTSQISGVHSNTSSNSGINENAVLPILSSSCPGWICYVEKTHSN-LIPNLSRVRSPQQ 244

  Fly   215 IMGVLVKQILADKMNVPASRIYHVTVMPCYDKKLEASREDFFSKANNSRDVDCVITSVEVEQLLS 279
            ..|.::|.....:.::..:.::|:::|||:||||||||::|  ..|..||||.|:|..|:.::..
pombe   245 ACGRILKDWAVQQFSMQRNDVWHLSLMPCFDKKLEASRDEF--SENGVRDVDSVLTPKELVEMFK 307

  Fly   280 EAQQPLSQYDLLDLDWPWSNVRPEFMVW----AHEKTL---SGGYAEHIFKYAAKHIFNEDLKTE 337
            ..:  :...:|.....|:.........|    .:|:.:   ||||..::..||||.:|..|....
pombe   308 FLR--IDPIELTKNPIPFQQSTDAIPFWYPRITYEEQIGSSSGGYMGYVLSYAAKMLFGIDDVGP 370

  Fly   338 LEFKQLKNRDFREIILK--QNGKTVLKFAIANGFRNIQNLVQKL--------------KR----- 381
            ......||.|..|..|:  :..:.::..|...|||||||||:::              ||
pombe   371 YVSMNNKNGDLTEYTLRHPETNEQLISMATCYGFRNIQNLVRRVHGNSSVRKGRVLLKKRVRSNA 435

  Fly   382 ----EKVSNYHFVEVMACPSGCINGGAQIR-PTTGQHV--RELTRKLEELYQNLPRSEP-ENSLT 438
                |:.|.|.:|||||||.||||||.|:. |:..:.|  |:..:::|:||.     || ..|:.
pombe   436 QNPTEEPSRYDYVEVMACPGGCINGGGQLPFPSVERIVSARDWMQQVEKLYY-----EPGTRSVD 495

  Fly   439 KHIYNDFLDGFQSDKSY--DVLHTRYHDVVSE 468
            :...:..|:.:..|.:.  ..|||.|..|.::
pombe   496 QSAVSYMLEQWVKDPTLTPKFLHTSYRAVQTD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17683	NP_001036428.1	Nar1	29..464	CDD:226972	166/518 (32%)
		Fe_hyd_lg_C	111..406	CDD:280978	114/370 (31%)
		Fe_hyd_SSU	419..465	CDD:214899	12/48 (25%)
SPCC1450.10c	NP_588309.1	Nar1	20..531	CDD:226972	171/529 (32%)
SPCC1450.10c	NP_588309.1	Fe_hyd_lg_C	98..463	CDD:280978	115/375 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	154	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E1_COG4624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I857
OMA	1	1.010	-	-		QHG54208
OrthoFinder	1	1.000	-	-		FOG0002027
OrthoInspector	1	1.000	-	-		oto101747
orthoMCL	1	0.900	-	-		OOG6_101268
Panther	1	1.100	-	-	LDO	PTHR11615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R794
SonicParanoid	1	1.000	-	-		X1333
TreeFam	1	0.960	-	-
	13	12.860