DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17683 and ciao3

DIOPT Version :9

Sequence 1:	NP_001036428.1	Gene:	CG17683 / 3355011	FlyBaseID:	FBgn0262115	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001106557.1	Gene:	ciao3 / 100127749	XenbaseID:	XB-GENE-987594	Length:	476	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	225/483 - (46%)
Similarity:	324/483 - (67%)	Gaps:	16/483 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRLSRALQLTDIDDFITPSQICIKPVQIDKARSKTGAKIKIKGDGCFEE--SESGNLKLNKVDIS 64
            |..|..|||||:||||.|||.||||::::|...:..|||:|:.||.:.:  .|....||.|..|:
Frog     3 SSFSGVLQLTDLDDFIGPSQECIKPIKVEKKAGRAAAKIQIEDDGSYVQINPEGAARKLEKAKIT 67

  Fly    65 LQDCLACSGCITSAEEVLITQQSREELLKVLQENSKNKASEDWDNVRTIVFTLATQPILSLAYRY 129
            |.||||||||:||||.:||||||.|||.|:|::|......|.    :.:|.:::.|...|||.|:
Frog    68 LNDCLACSGCVTSAETILITQQSHEELYKILKQNKTENPLEH----KVVVVSVSPQSWASLAARF 128

  Fly   130 QIGVEDAARHLNGYFRSLGADYVLSTKVADDIALLECRQEFVDRYR----ENENLTMLSSSCPGW 190
            .:.::|.|:.|..:|:.||..:|..|..:.:.:|||.::||:.|::    :.::|.||:|:||||
Frog   129 NLIMQDTAQKLTAFFKQLGVHHVFDTNFSRNFSLLESQREFIQRFKRQKEDKKSLPMLASACPGW 193

  Fly   191 VCYAEKTHGNFLLPYVSTTRSPQQIMGVLVKQILADKMNVPASRIYHVTVMPCYDKKLEASREDF 255
            :||||||||:|:|||:|:|:||||:||.|||...|.:.|:..::||||||||||||||||||.||
Frog   194 ICYAEKTHGSFILPYISSTKSPQQVMGSLVKSHFAKEKNLKPNQIYHVTVMPCYDKKLEASRPDF 258

  Fly   256 FSKANNSRDVDCVITSVEVEQLLSEAQQPLSQYDLLDLDWPWSNVRPEFMVWAHEKTLSGGYAEH 320
            :::...:|:||||||:.||.::|.:....||..|...||..:.:...|..| .|:...||||.||
Frog   259 YNQEYETREVDCVITTGEVLRMLEQEGLSLSDVDPSPLDTLFGSAVQEEPV-GHQGGGSGGYLEH 322

  Fly   321 IFKYAAKHIFNEDLKTELEFKQLKNRDFREIILKQNGKTVLKFAIANGFRNIQNLVQKLKREKVS 385
            :|::||:.:|...:.| :.:|.|||:||:|:.|:|:|..||.||:|.||||||||||||||.:..
Frog   323 VFRHAAQELFGVHVDT-VVYKPLKNKDFQEVTLEQDGNVVLHFALAYGFRNIQNLVQKLKRGRCP 386

  Fly   386 NYHFVEVMACPSGCINGGAQIRPTTGQHVRELTRKLEELYQNLPRSEP-ENSLTKHIYNDFLDGF 449
             ||:||||||||||:|||.||: ..|:..::|.:::|:||..:....| |......:|.|:|:..
Frog   387 -YHYVEVMACPSGCLNGGGQIK-AEGEGSKDLLQRVEDLYNTVRTERPEEREEVAQLYGDWLEDK 449

  Fly   450 QSDKSYDVLHTRYHDVVSELSISLNINW 477
            .|.|:...|||:|| .|.:::..|.|.|
Frog   450 DSAKARQALHTQYH-AVEKINSGLTIKW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17683	NP_001036428.1	Nar1	29..464	CDD:226972	202/441 (46%)
		Fe_hyd_lg_C	111..406	CDD:280978	146/298 (49%)
		Fe_hyd_SSU	419..465	CDD:214899	15/46 (33%)
ciao3	NP_001106557.1	Nar1	61..462	CDD:226972	192/408 (47%)
		Fe_hyd_lg_C	118..406	CDD:280978	145/290 (50%)
		Fe_hyd_SSU	418..466	CDD:214899	15/48 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6750
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1678
OMA	1	1.010	-	-		QHG54208
OrthoDB	1	1.010	-	-		D370258at33208
OrthoFinder	1	1.000	-	-		FOG0002027
OrthoInspector	1	1.000	-	-		otm49056
Panther	1	1.100	-	-	LDO	PTHR11615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R794
SonicParanoid	1	1.000	-	-		X1333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110