DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS3 and INTS3

DIOPT Version :9

Sequence 1:	NP_001036437.1	Gene:	IntS3 / 3355010	FlyBaseID:	FBgn0262117	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001311404.1	Gene:	INTS3 / 65123	HGNCID:	26153	Length:	1042	Species:	Homo sapiens

Alignment Length:	1095	Identity:	424/1095 - (38%)
Similarity:	639/1095 - (58%)	Gaps:	127/1095 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCKE-KQHEEISIGFLYIMLT 77
            :|.:.|::|.||::||:.||....:....:|:|::|.:|.|:..|||. .|||||.:|...::||
Human    35 RLLLSTSLDAKDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILT 99

  Fly    78 DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVI 142
            :|:.|.|.|||:.||||||||.::..:..::.|||.||.:..|.||:||:||.||..||..:.|.
Human   100 EPAQAQKCYRDLALVSRDGMNIVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVC 164

  Fly   143 WNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPA-LLSLR 206
            ...::|..||||:::|::|.||:|||..|.|.|:..:..|:...||:::|||.||...| |.:||
Human   165 MTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALR 229

  Fly   207 QKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHI 271
            ||||.|.|||:||||.:.:.:|||.||||||||||||||.||:||:.||:.|...|.||.|||..
Human   230 QKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQS 294

  Fly   272 RTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHP 336
            ||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:||:|.|||.||||:|..|:||
Human   295 RTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP 359

  Fly   337 TNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIR 401
            :|::|.|||:|||||||||:::||:.:|::||||:||||||||.|.||:||||||.||||:||::
Human   360 SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMK 424

  Fly   402 NHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLI 466
            .||.:::|||||:|||..||:...|..:|.||::||..|:||:|:.:|.|||::||||:|||.::
Human   425 PHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRAML 489

  Fly   467 RDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCENMDLHETGLINISGTIDEDKKIL 531
            |:.|.||.|.|:          .||:..|.:..|.:       ||.|.:         |:|:...
Human   490 REKFPEFCSSPS----------PPVEVKIEEPVSME-------MDNHMS---------DKDESCY 528

  Fly   532 LVPTDQEIESVFSDETAENLR--------RVHNIEDNTDD------------DDDLPLSEVRLKE 576
                 ...|:.|||: .|:|.        |.|.|::...:            |:.|....::|::
Human   529 -----DNAEAAFSDD-EEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDESLRDKVLQLQK 587

  Fly   577 KPKVEL-AEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEE-FQLNYVISNTVLILRETLPQ 639
            ....|. .|.:.|..|..:.       |.|..:...:.||..:| |:.::        ..|.||
Human   588 GSDTEAQCEVMQEIVDQVLE-------EDFDSEQLSVLASCLQELFKAHF--------RGEVLP- 636

  Fly   640 QNIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMK 702
                 |..|||. |.:|:..|||.:||.|  .:.|..|......||||:.:..|:|||.|||:::
Human   637 -----EEITEES-LEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLR 695

  Fly   703 IYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKS 767
            .......:.|..:|:...|    |:.|     :..||:.|:...::::..:...|.|.||.||..
Human   696 ASKAAAGKMNLYESFAQAT----QLGD-----LHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPD 751

  Fly   768 IATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQA 832
            ....:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||:||:|.||:..|
Human   752 ETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLA 816

  Fly   833 HDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPFVTSALRFWC 897
            |::||..|..||..|:...||||||..||.|:.|:|:.|:::::|||.. ...|.|.||.||.||
Human   817 HNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPC-HPDDQFTTSILRHWC 880

  Fly   898 QRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLNHLEHYRRSCRHG 957
            .:::|.|:|.|.|||...  :|.|.||:      |:.:|:.     :.:|:|.||::.|.:..:
Human   881 MKHDELLAEHIKSLLIKN--NSLPRKRQ------SLRSSSSKLAQLTLEQILEHLDNLRLNLTN- 936

  Fly   958 TGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTTV----GRRGGSGRGRKQPGSK 1017
            |....:....:.:|||...:..:::.|.:|.|||:||.| ||::.    .||..:   ...|.|:
Human   937 TKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAA---LSSPRSR 998

  Fly  1018 KDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN----NDSD 1068
            |    :.|...|.|.    .|...::|||:.:|.|   ..||::|.:    :|||
Human   999 K----NATQPPNAEE----ESGSSSASEEEDTKPK---PTKRKRKGSSAVGSDSD 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	DUF2356	247..471	CDD:287198	133/223 (60%)
INTS3	NP_001311404.1	Ints3	270..494	CDD:370870	133/223 (60%)
INTS3	NP_001311404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1042		20/79 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152591
Domainoid	1	1.000	298	1.000	Domainoid score	I1460
eggNOG	1	0.900	-	-		E1_KOG4262
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11309
Inparanoid	1	1.050	690	1.000	Inparanoid score	I696
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49472
OrthoDB	1	1.010	-	-		D58799at33208
OrthoFinder	1	1.000	-	-		FOG0006156
OrthoInspector	1	1.000	-	-		oto91642
orthoMCL	1	0.900	-	-		OOG6_105426
Panther	1	1.100	-	-	LDO	PTHR13587
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4237
SonicParanoid	1	1.000	-	-		X5090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800