Protein Alignment IntS3 and ints3

DIOPT Version :10

• Sequence 1: NP_001036437.1
• Gene: IntS3 / 3355010
• FlyBaseID: FBgn0262117
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001038397.1
• Gene: ints3 / 560575
• ZFINID: ZDB-GENE-060503-634
• Length: 1017
• Species: Danio rerio
• Alignment Length: 1104
• Identity: 408/1104 - (36%)
• Similarity: 640/1104 - (57%)
• Gaps: 123/1104 - (11%)

  Fly     1 MEQQQSKNNAHVSKLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCK-EKQH 64
            ||...:|..|. .:|.:.|::|.||::||:.||.........:|||::|.:|.|:..||| .:||
Zfish     1 MEPSPAKGKAQ-GRLLVSTSLDAKDELEERLERCMSITTSITNGLSEREANDALTAHVCKGPQQH 64

  Fly    65 EEISIGFLYIMLTDPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLRE 129
            ||:.:|...::||:|..|.:.|||:|||:|||||.::..:..::.||:.||.:|.|.||:||:||
Zfish    65 EEVCLGLFTLLLTEPPQAQRCYRDLTLVNRDGMNVVLMKINQILMEKFLKLQDVCRTQLVWLVRE 129

  Fly   130 FVKHQVLSVENVIWNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLI 194
            .||..|:..:.|:...::|..|||:||:||:|.|::|||.::.|.|:..:..||..::|:::|||
Zfish   130 LVKSGVIGADGVLMTLMKQIAGGDISSKNLWLAENVLDILVDQREWVLKSGMLVAMSLYTYLRLI 194

  Fly   195 EDHANPALLSLRQKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLH 259
            .||...:||.|||:||.|.|.|:||||.:...:|||.||||||||||||.|.:|||:|.:|:.|.
Zfish   195 VDHGTTSLLPLRQREVDFCIGLLRERFMECFIIGRDLVRLLQNVARIPEMELVWRDLLHSPQTLS 259

  Fly   260 QTFNGIWQLLHIRTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRS 324
            ..|.||.|||..||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:|.||.|||.
Zfish   260 PQFTGILQLLTSRTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTAESQSLRC 324

  Fly   325 DLIRFIINVIHPTNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNI 389
            ||||:|..|:||:|::|.|||:|||||||||:::||:.:|::||||:||||||||:|.||:||||
Zfish   325 DLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFNPEKDSIMNI 389

  Fly   390 EPGILVMYHSIRNHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFE 454
            ||.||||:||::.||.:::|||||:|||..:||...|.::|.||:|||..|:||:|:.:|.|||:
Zfish   390 EPAILVMHHSMKPHPAITATLLDFMCRIIPHFFPPLEGQVRQGVFNSLNFIMEKRVLAHLAPLFD 454

  Fly   455 SPKLDRELRNLIRDNFREFLSPPANHGQLLFTSLHPVQ--GHILKKESDQRILHCENMDLHETGL 517
            :||||||||:::|:.|.||.|.|:...::......|::  .|:|.||..     |.:
Zfish   455 NPKLDRELRSMLRERFPEFCSSPSPPTEVKMEESVPLEMDNHVLDKEDG-----CYD-------- 506

  Fly   518 INISGTIDEDKKIL-----------------LVPTDQEIESVFSDETAENLR-RVHNIEDNTDDD 564
             |...|..:|::.|                 .:....:| :.|.|:..|.|: ||..::..:|.:
Zfish   507 -NTDATFSDDEEELNNKGKKREFRFHQLKETYIDEPSDI-TPFVDQLDEALKERVLQLQKGSDTE 569

  Fly   565 DDLPLSEVRLKEKPKVELAEAI-AESFDAFVTKRNSYTWEAFLKDFRPLPASAFEEFQLNYVISN 628
            ....:.:         |:.:.| .|.||:              :....|.:...|.|:.::
Zfish   570 THCEVMQ---------EIVDLILEEDFDS--------------EQMSTLASCLAELFKSHF---- 607

  Fly   629 TVLILRETLPQQNIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIP 691
                      :.::..|..|||. |.:|:..|:..:||.|  .:.|.........||:|:.:..|
Zfish   608 ----------RGDVLPEEITEES-LEESVCKPVCLIFRNLCQMQEDNSGFSVLLDLLAELYQKQP 661

  Fly   692 EIGYLLLYFMKIYCKLQTRKNSQQSYQFKTTIYRQICDA-ADEKIGNCLLRDLDLLEKENTNIFL 755
            :|||.|||::|          :.::...|.::|.....| |...:..||:.|:...::::..:..
Zfish   662 KIGYHLLYYLK----------ASKAASGKMSLYESFAQATALGDLHTCLMMDMKACQEDDVRLLC 716

  Fly   756 WLLPDIYREFKSIATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFET 820
            :|.|.||.||......:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||
Zfish   717 YLTPSIYSEFPDETLRSGELLNMIVAVIDSAQLQELMCHVMMGNLVMFRKDSVLNILIQSLDWET 781

  Fly   821 YEQFCLWQIVQAHDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKG 885
            :||:..||:..||.:||..|..||..|:...||||||..||.|:.|:|:.|:::::|||....:
Zfish   782 FEQYSTWQLFLAHSIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPYHQE- 845

  Fly   886 DPFVTSALRFWCQRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLN 945
            |.|.||.||.|..::::.|.|.|.:||...  ::.|.||:      |:.:|:.     :.:|:|.
Zfish   846 DQFTTSILRHWTAKHDDLLGEHIKALLIKN--NNMPRKRQ------SLRSSSSKLAQLTLEQMLE 902

  Fly   946 HLEHYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTTVGRRGGSGR 1009
            ||:..|.|..: |....:....:.:|||...:..:::.|.:|.|||:||.| ||::...:.
Zfish   903 HLDSLRLSLSN-TKNNFFSQTPILQALQHVQASCDEAHKMRFSDLFSLAEEYEDSSKPPKS---- 962

  Fly  1010 GRKQPGSKKDVNNHGTSKKN--PEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN---NDSD 1068
            .||.|.|..      .|:|.  |:......|...::|||:.||.|   .:||::|.:   :|||
Zfish   963 RRKAPASSP------RSRKGAAPQPCNEEESVSSSASEEEDSKPK---ASKRKRKGSAVGSDSD 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	Ints3_N	62..467	CDD:431123	222/404 (55%)
ints3	NP_001038397.1	Ints3_N	62..468	CDD:431123	222/405 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	952..1017		21/77 (27%)