DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS3 and Ints3

DIOPT Version :9

Sequence 1:	NP_001036437.1	Gene:	IntS3 / 3355010	FlyBaseID:	FBgn0262117	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_663515.2	Gene:	Ints3 / 229543	MGIID:	2140050	Length:	1041	Species:	Mus musculus

Alignment Length:	1095	Identity:	424/1095 - (38%)
Similarity:	640/1095 - (58%)	Gaps:	127/1095 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCK-EKQHEEISIGFLYIMLT 77
            :|.:.|::|.||::||:.||....:....:|:|::|.:|.|:..||| ..|||||.:|...::||
Mouse    34 RLLLSTSLDAKDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGPPQHEEICLGLFTLVLT 98

  Fly    78 DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVI 142
            :|:.|.|.|||:.||||||||.::..:..|:.|||.||.:..|.||:||:||.||..||..:.|.
Mouse    99 EPAQAQKCYRDLALVSRDGMNIVLNKINQLLMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVC 163

  Fly   143 WNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPA-LLSLR 206
            ...::|..||||:::|::|.||:|||..|.|.|:..:..|:...||:::|||.||...| |.:||
Mouse   164 MTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQTLR 228

  Fly   207 QKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHI 271
            ||||.|.|||:||||.:.:.:|||.||||||||||||||.||:||:.||:.|...|.||.|||..
Mouse   229 QKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQS 293

  Fly   272 RTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHP 336
            ||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:||:|.|||.||||:|..|:||
Mouse   294 RTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP 358

  Fly   337 TNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIR 401
            :|::|.|||:|||||||||:::||:.:|::||||:||||||||.|.||:||||||.||||:||::
Mouse   359 SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMK 423

  Fly   402 NHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLI 466
            .||.:::|||||:|||..||:...|..:|.||::||..|:||:|:.:|.|||::||||:|||:::
Mouse   424 PHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRSML 488

  Fly   467 RDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCENMDLHETGLINISGTIDEDKKIL 531
            |:.|.||.|.|:          .||:..|.:..|.:       ||.|.:         |:|:...
Mouse   489 REKFPEFCSSPS----------PPVEVKIEEPVSME-------MDNHLS---------DKDESCY 527

  Fly   532 LVPTDQEIESVFSDETAENLR--------RVHNIEDNTDD------------DDDLPLSEVRLKE 576
                 ...|:.|||: .|:|.        |.|.|::...:            |:.|....::|::
Mouse   528 -----DNAEAAFSDD-EEDLNSKGKKREFRFHPIKETVVEEPVDVTPYLDQLDESLRDKVLQLQK 586

  Fly   577 KPKVEL-AEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEE-FQLNYVISNTVLILRETLPQ 639
            ....|. .|.:.|..|..:.       |.|..:...:.||..:| |:.::        ..|.||
Mouse   587 GSDTEAQCEVMQEIVDQVLE-------EDFDSEQLSVLASCLQELFKAHF--------RGEVLP- 635

  Fly   640 QNIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMK 702
                 |..|||. |.:|:..|||.:||.|  .:.|..|......||||:.:..|:|||.|||:::
Mouse   636 -----EEVTEES-LEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLR 694

  Fly   703 IYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKS 767
            .......:.|..:|:...|    |:.|     :..||:.|:...::::..:...|.|.||.||..
Mouse   695 ASKAAAGKMNLYESFAQAT----QLGD-----LHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPD 750

  Fly   768 IATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQA 832
            ....:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||:||:|.||:..|
Mouse   751 ETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLA 815

  Fly   833 HDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPFVTSALRFWC 897
            |::||..|..||..|:...||||||..||.|:.|:|:.|:::::|||.. ...|.|.||.||.||
Mouse   816 HNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPC-HPDDQFTTSILRHWC 879

  Fly   898 QRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLNHLEHYRRSCRHG 957
            .:::|.|:|.|.:||...  :|.|.||:      |:.:|:.     :.:|:|.||::.|.:..:
Mouse   880 MKHDELLAEHIKALLIKN--NSLPRKRQ------SLRSSSSKLAQLTLEQILEHLDNLRLNLAN- 935

  Fly   958 TGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTTV----GRRGGSGRGRKQPGSK 1017
            |....:....:.:|||...:..:::.|.:|.|||:||.| ||::.    .||..:   ...|.|:
Mouse   936 TKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAA---LSSPRSR 997

  Fly  1018 KDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN----NDSD 1068
            |    :.|...|.|.    .|...::|||:.:|.|   ..||::|.:    :|||
Mouse   998 K----NATQPPNAEE----ESGSSSASEEEDTKPK---PTKRKRKGSSAVGSDSD 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	DUF2356	247..471	CDD:287198	133/223 (60%)
Ints3	NP_663515.2	Ints3	269..493	CDD:313427	133/223 (60%)
Ints3	NP_663515.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1041		20/79 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842650
Domainoid	1	1.000	299	1.000	Domainoid score	I1446
eggNOG	1	0.900	-	-		E1_KOG4262
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11309
Inparanoid	1	1.050	691	1.000	Inparanoid score	I686
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49472
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006156
OrthoInspector	1	1.000	-	-		oto95224
orthoMCL	1	0.900	-	-		OOG6_105426
Panther	1	1.100	-	-	LDO	PTHR13587
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4237
SonicParanoid	1	1.000	-	-		X5090
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790