DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS3 and INT3_ANOGA

DIOPT Version :9

Sequence 1:	NP_001036437.1	Gene:	IntS3 / 3355010	FlyBaseID:	FBgn0262117	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_003436148.1	Gene:	INT3_ANOGA / 1273424	VectorBaseID:	AGAP002539	Length:	1209	Species:	Anopheles gambiae

Alignment Length:	1209	Identity:	602/1209 - (49%)
Similarity:	788/1209 - (65%)	Gaps:	167/1209 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCKEKQHEEISIGFLYIMLTD 78
            |||:.| :|.:|:.|||:.|::...:...:|||||:.||:||..|.|||||||||:..:||:|||
Mosquito    14 KLFVQT-IDARDENEEKYMRAYRAFEETTAGLSDKDFHDLLSSLVSKEKQHEEISLALVYIILTD 77

  Fly    79 PSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVIW 143
            ||.|.|||||:||::|||:..:..||..||||||.|||:|.|:||:|||||.:|:|||:|:|:.|
Mosquito    78 PSSAPKTYRDLTLLTRDGLGFVTANLAMLVAEKYHKLTDVGRKQLLWLLRELIKNQVLNVDNLAW 142

  Fly   144 NCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPALLSLRQK 208
            |.||||.|||:|.:|:.|||.|||||.|.|.|||.:.|||.:..|:||||||||..|..:.||.:
Mosquito   143 NILRQASGGDISPKNVALIEGLLDIFTEHRAWLEKDQFLVGTVAYTFVRLIEDHFGPQFVHLRNR 207

  Fly   209 EVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHIRT 273
            ||||.|||||:||.|||||||:||||||||.|||||:|||:|:|:|||.|..||||:||||..||
Mosquito   208 EVKFVISLIRDRFMDIIPLGREFVRLLQNVGRIPEFDQLWKDMLYNPKSLCPTFNGVWQLLQTRT 272

  Fly   274 SRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTN 338
            |||||:.||.|::||||.||.|:||||||||||||||::||.||||.|||.|||||||:.|||||
Mosquito   273 SRRFLRGRLTPDIERKIHFLTSNVKFGNQKRYQDWFQERYFNTPESQSLRCDLIRFIISAIHPTN 337

  Fly   339 DMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIRNH 403
            |||||||||||||||||::||||.:..|||||:|||||||||||||||||:|||||||||||:||
Mosquito   338 DMLCSDIIPRWAIIGWLLTSCTNAVTLANAKLALFYDWLFFDPAKDNIMNVEPGILVMYHSIKNH 402

  Fly   404 PFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLIRD 468
            |.||.|||||||||.|||:.|.||:||.|:||||:.|||.:|||||.||||||||||||:.::|:
Mosquito   403 PLVSCTLLDFLCRIMKNFYPKWEDRIRTGIYNSLRKILEMKVIPNLVPLFESPKLDRELKGMLRE 467

  Fly   469 NFREFLSPPAN-------------------------------------HGQLLFTSLHPVQGHI- 495
            .||||..||.:                                     |..::.|::||.|..|
Mosquito   468 TFREFCVPPNSMYMHPGPPQPGMETPMMMHYPGPGGGEQVEQHPPHLMHPSMMHTTVHPGQTDIT 532

  Fly   496 -LKKESDQRILHCE-------------------------------------------------NM 510
             |.:....|..|..                                                 .|
Mosquito   533 QLNRMDPSRKAHDSGGGGGGGGGGGGGQVGMGPGWLALRGPMAAGVGTMPVTQGARGGPPGGPGM 597

  Fly   511 DLHETGLINISG-------------------------------------------TIDEDKKILL 532
            .|...|...:.|                                           ...:|.|.
Mosquito   598 MLAGGGGGGVGGGAAAVASGAPFSGGGMAGPAAGTPFIKPEPPRTDSAAKAASTAASADDPKF-- 660

  Fly   533 VPTDQEIESVFSDETAENLRRVHNIEDNTDDDDDLPLSEVRLKEKP---KVELAEAIAESFDAFV 594
              :|.|.::.....|...........::..|||||||::|||.|||   ||.|.:.:....:.|:
Mosquito   661 --SDDEDDATTKPATTTTTTTTTTKTEDVSDDDDLPLAKVRLLEKPAIAKVALPDTLNGHLEEFL 723

  Fly   595 TKRNSYTWEAFLKDFRPLPASAFEEFQLNYVISNTVLILRETLPQQNIFSESKTEEKHLAKSISY 659
            .:::..|:|..|:.......:|..:.|.||:..:.:.::::|||.::.|..|||:: :|::||:|
Mosquito   724 REKSVKTFEPLLQCLGSCGKAALNQEQENYLTESVISVIKQTLPDKSYFPASKTDD-NLSESINY 787

  Fly   660 PLYGLFRFLYENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMKIYCKLQTRKNSQQ--SYQFKTT 722
            ||:..:|.||:.::..||....||..|...:...||:||||:|::.|||.|:....  |..||.:
Mosquito   788 PLFAAYRLLYQQEDSCKKRVMALLVAIVTRVSVAGYMLLYFLKVHGKLQGRRKETAGGSTAFKAS 852

  Fly   723 IYRQICDAAD--EKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKSIATNNTDLLRITLRCIDA 785
            :|..:|||.|  :.:..|:.:||:||||.||.:|||:|||:|||||....|||.:||:.:.||||
Mosquito   853 VYGVLCDALDSVDSVDECIEKDLNLLEKHNTQMFLWILPDMYREFKQTMLNNTTVLRLLVGCIDA 917

  Fly   786 KNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQAHDVPLRCIQDILPELEAG 850
            .|:.||:|||.||||.:|.:||:::.:|:|||:||:||.|:||:|||||:||...|:|:||||:|
Mosquito   918 NNLGDIIYSITQGKLILFDEDGIVEILRKSLEYETFEQVCIWQLVQAHDIPLETFQEIIPELESG 982

  Fly   851 SHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSK--GDPFVTSALRFWCQRYEEKLSEIIASLLT 913
            :|.|||:..||||:.|:||.|::||:||||::||  |||||||.||:|||.:||||||:||:|||
Mosquito   983 AHAEALTAILLLLRAEKPTTELVRLLLSRETESKHRGDPFVTSVLRYWCQEFEEKLSELIAALLT 1047

  Fly   914 SKYPSSSPNKRKRPPKGISVSTSTPSADQVLNHLEHYRRSCRH--GTGTGLYVHDMMQRALQSAY 976
            |||||:||||||||.|....:|: |:::|:||||||:||||||  ||||||:|.:.||||||.|:
Mosquito  1048 SKYPSNSPNKRKRPSKSAQQNTA-PTSEQLLNHLEHFRRSCRHGNGTGTGLFVQNDMQRALQQAF 1111

  Fly   977 SHSNDSTKKQFCDLFALAAEED--TTVGRRGGSGRGRKQPGSKKD----------VNNHGTSKKN 1029
            :||::|.:|||.||||||||::  |||||||.|.||||.|.:||:          ...|..:.|.
Mosquito  1112 THSSESQRKQFSDLFALAAEDETSTTVGRRGTSSRGRKAPSNKKETAAEKAAAAAAAAHANNSKK 1176

  Fly  1030 PEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKANNDSD 1068
            .......:|  |:||:|||||.|    |.:|:|..:|||
Mosquito  1177 AAEASAKFS--DDSSDEDWSKQK----ASKRRKTLSDSD 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	DUF2356	247..471	CDD:287198	170/223 (76%)
INT3_ANOGA	XP_003436148.1	DUF2356	246..470	CDD:287198	170/223 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	514	1.000	Domainoid score	I1113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11309
Inparanoid	1	1.050	1165	1.000	Inparanoid score	I651
OMA	1	1.010	-	-		QHG49472
OrthoDB	1	1.010	-	-		D58799at33208
OrthoFinder	1	1.000	-	-		FOG0006156
OrthoInspector	1	1.000	-	-		oto111283
Panther	1	1.100	-	-	LDO	PTHR13587
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5090
TreeFam	0	0.000	Not matched by this tool.
	11	11.080