DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS3 and ints3

DIOPT Version :9

Sequence 1:	NP_001036437.1	Gene:	IntS3 / 3355010	FlyBaseID:	FBgn0262117	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_031746762.1	Gene:	ints3 / 101733079	XenbaseID:	XB-GENE-5719966	Length:	1027	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	415/1104 - (37%)
Similarity:	639/1104 - (57%)	Gaps:	133/1104 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCK-EKQHEEISIGFLYIMLT 77
            ||.|.|.:|.||::||:.||....:....:|:|::|.:|.|:..||| ..||||:.:|...::||
Frog     8 KLLITTGLDAKDELEERLERCMALVNSMTNGMSEREANDALNAYVCKGATQHEEVCLGLFALVLT 72

  Fly    78 DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVI 142
            :|:...|:|||:..:||||||.::..:..|:.|||.||.:..|.||:||:||.||..||..:.|.
Frog    73 EPAQVQKSYRDLAFISRDGMNIVLNKINQLLMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVC 137

  Fly   143 WNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIED-HANPALLSLR 206
            ...::|..|||:|::|::|.|::|||.:|.|.|:..:..|:..:||:::|||.| |..|.|.:||
Frog   138 MTFMKQIAGGDISAKNIWLAENVLDILMEQREWVMKSSILIAMSVYTYLRLIVDHHGTPPLQALR 202

  Fly   207 QKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHI 271
            ||||:|.:.|:||||.|...:|||.|||||||||||||:.||:|:|.||:.|:..|.||.|||..
Frog   203 QKEVEFCMMLLRERFMDCFMIGRDLVRLLQNVARIPEFDLLWKDMLHNPQALNPQFTGILQLLQS 267

  Fly   272 RTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHP 336
            ||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:||:|.|||.||||:|..|:||
Frog   268 RTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP 332

  Fly   337 TNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIR 401
            :|::|.|||:|||||||||:::||:.:|::||||:||||||||.|.||:||||||.||||:||::
Frog   333 SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMK 397

  Fly   402 NHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLI 466
            .||.:::|||||:|||..||:...|..:|.||::||..|:||:|:.:|.|||.:||||:|||:::
Frog   398 PHPAITATLLDFMCRIIPNFYPTLEGNVRQGVFSSLTHIMEKRVLAHLAPLFHNPKLDKELRSML 462

  Fly   467 RDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCEN--MDLHETGLINISGTIDEDKK 529
            |:.|.||.:.|:...::              |..:...:..||  .|..::...|......:|
Frog   463 REKFPEFCALPSPASEI--------------KTEEPTSMEMENNMADKEDSCYDNAEAAFSDD-- 511

  Fly   530 ILLVPTDQEIESVFSDETAENLRRVHN-----IEDNTDDDDDLPLSEVRLKEK-----------P 578
                  |:|:.:..::...:...|.|.     ||:..|....:...:.:||:|           .
Frog   512 ------DEEVNNKTNETGKKREFRFHPIKEPIIEEPVDISPYVDQLDEQLKDKVVALQKESDMEA 570

  Fly   579 KVELAEAIAESF--DAFVTKRNSYTWEAFLKDFRPLPASAFEE-FQLNYVISNTVLILRETLPQQ 640
            :.|:.:.|.|..  |.|.|::::            :.||..:| |:.::        ..|.||
Frog   571 QCEIMQEIVEQILEDDFDTEQSA------------VVASCLQELFKAHF--------RGEVLP-- 613

  Fly   641 NIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMKI 703
                |..|||. |.:|:..|||.:||.|  .:.|.........||||:.:..|:|||.|||::|.
Frog   614 ----EEITEES-LEESVGKPLYLIFRNLIQMQEDNSGFSILLDLLSELYQRQPKIGYHLLYYLKA 673

  Fly   704 YCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKSI 768
            ......:.|..:|:...|    |:.|     :..||:.|:...::::..:..:|.|.||.||...
Frog   674 SKAASGKMNLYESFAQAT----QLGD-----LHTCLMMDMKACQEDDVRLLCYLTPSIYSEFPDE 729

  Fly   769 ATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQAH 833
            ...:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||:||:|.||:..||
Frog   730 TLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCTWQLFLAH 794

  Fly   834 DVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPFVTSALRFWCQ 898
            ::||..|..||..|:...||||||..||.|:.|:|:.|:::::|||....: |.|.||.||.|..
Frog   795 NIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPCHPE-DQFTTSILRHWGL 858

  Fly   899 RYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLNHLEHYR------- 951
            :|::.|:|.|.|||...  :|.|.||:      |:.:|:.     :.:|:|.||:..|
Frog   859 KYDDHLAENIKSLLIKN--NSLPRKRQ------SLRSSSSKLAQLTLEQILEHLDGLRLNLSNTK 915

  Fly   952 RSCRH-GTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTT---VGRRGG---SG 1008
            ::|.: |....::....:.:|||...:..:::.|.:|.||||||.| ||:|   ..||.|   |.
Frog   916 QNCEYRGAHLAVFSQTPILQALQHVQASCDEAHKMKFSDLFALAEEYEDSTKPPKSRRKGPMTSP 980

  Fly  1009 RGRKQPGSKKDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN----NDSD 1068
            |.||......:....              |:..::|||:.:|.|   ..||::|.:    :|||
Frog   981 RSRKNTAQPLNTEEE--------------SASSSASEEEDTKPK---PTKRKRKGSSAVGSDSD 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	DUF2356	247..471	CDD:287198	133/223 (60%)
ints3	XP_031746762.1	Ints3	243..467	CDD:401995	133/223 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1090
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D58799at33208
OrthoFinder	1	1.000	-	-		FOG0006156
OrthoInspector	1	1.000	-	-		oto105410
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060