DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17168 and SNIP1

DIOPT Version :9

Sequence 1:	NP_001015254.1	Gene:	CG17168 / 3354996	FlyBaseID:	FBgn0039943	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_078976.2	Gene:	SNIP1 / 79753	HGNCID:	30587	Length:	396	Species:	Homo sapiens

Alignment Length:	433	Identity:	170/433 - (39%)
Similarity:	232/433 - (53%)	Gaps:	77/433 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KQRNKEHELEQQRTGHEGDTKMSDRNLSKTKKIK--------QRATADSSSSSDSSNESKKSNH- 58
            |....|.|...:|...:||..:....:.|.:::.        :|......|.|..::|..:|.|
Human     2 KAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHR 66

  Fly    59 -------SSLSPNRKQRTAGKRQRDSSQSQEKRHKQLTHPSEDVHEQRSKWDSPERSNSHRNSTR 116
                   |...|.:|.:.:|:|   |...:.||::...|.:..|.::|.  |.|.|....|
Human    67 GNRARGVSRSPPKKKNKASGRR---SKSPRSKRNRSPHHSTVKVKQERE--DHPRRGREDR---- 122

  Fly   117 QRRNTRSRSRERSERERDRDCERNKERDYNMQSSKERWQRSPALRHRSRSSERKNRERDRQRRPT 181
                   :.||.||:|..|  .||.:||                |||..|         .|||.:
Human   123 -------QHREPSEQEHRR--ARNSDRD----------------RHRGHS---------HQRRTS 153

  Fly   182 ERRPVRRSQSPRDRCHGGRDLDQRRQRNQRHN---NSNKNEDDHYVWGKEVDEKVP------AEN 237
            ..||.......|||  ..::|..:.:..:.:|   ..::..:|....|.|..|.||      .|.
Human   154 NERPGSGQGQGRDR--DTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEK 216

  Fly   238 DVPVDKEKPNFGLSGALTEDTNKLNGVVVKYSEPPEARKPKRRWRLYPFKGETALPTLHIHRQSC 302
            :||. ||||:|.|||||.||||...|||:|||||||||.||:||||||||.:..||.::|||||.
Human   217 EVPA-KEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSA 280

  Fly   303 FLVGRDRKVVDLAVDHPSCSKQHAALQYRLVPFEREDGSHGKRVRLYLIDLDSANGTFLNNKKID 367
            :|:||.|::.|:.:||||||||||..|||||.:.|.||:.|:||:.|:|||.|.||||||||:|:
Human   281 YLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIE 345

  Fly   368 ARKYYELIEKDVIKFGFSSREYVLLHENS------KEDQEDDD 404
            .::||||.||||:||||||||||||||:|      ::|.||::
Human   346 PQRYYELKEKDVLKFGFSSREYVLLHESSDTSEIDRKDDEDEE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17168	NP_001015254.1	FHA	280..395	CDD:238017	76/114 (67%)
CG17168	NP_001015254.1	FHA	<294..411	CDD:224630	71/117 (61%)
SNIP1	NP_078976.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..227		65/270 (24%)
		PRK12678	24..>208	CDD:237171	51/228 (22%)
		FHA	258..361	CDD:238017	64/102 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..396		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147906
Domainoid	1	1.000	129	1.000	Domainoid score	I5301
eggNOG	1	0.900	-	-		E1_KOG1882
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3033
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52032
OrthoDB	1	1.010	-	-		D955935at2759
OrthoFinder	1	1.000	-	-		FOG0004489
OrthoInspector	1	1.000	-	-		oto90534
orthoMCL	1	0.900	-	-		OOG6_102703
Panther	1	1.100	-	-	LDO	PTHR23308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2234
SonicParanoid	1	1.000	-	-		X4267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800