DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17168 and PPP1R8

DIOPT Version :9

Sequence 1:	NP_001015254.1	Gene:	CG17168 / 3354996	FlyBaseID:	FBgn0039943	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_054829.2	Gene:	PPP1R8 / 5511	HGNCID:	9296	Length:	351	Species:	Homo sapiens

Alignment Length:	145	Identity:	47/145 - (32%)
Similarity:	70/145 - (48%)	Gaps:	21/145 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 PPEARKPKRRWRLYPFKGETALPTLHIHRQSCFLVGRDRKVVDLAVDHPSCSKQHAALQYRLVPF 335
            |..|.||.....|...||:..:..|.|..:..:|.||:..:.|..:||.|||:.||||.|.
Human    17 PTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYH---- 77

  Fly   336 EREDGSHGKRVRLYLIDLDSANGTFLNNKKIDARKYYELIEKDVIKFGFSSREYVLLHE------ 394
                 .|.|||  :||||:|.:||||.:.:::..|..::.....:.||.|:|.|.|..:
Human    78 -----KHLKRV--FLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPS 135

  Fly   395 ----NSKEDQEDDDV 405
                :.|...|||::
Human   136 AVKGDEKMGGEDDEL 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17168	NP_001015254.1	FHA	280..395	CDD:238017	39/124 (31%)
CG17168	NP_001015254.1	FHA	<294..411	CDD:224630	40/122 (33%)
PPP1R8	NP_054829.2	Interaction with CDC5L, SF3B1 and MELK. /evidence=ECO:0000269\|PubMed:10827081, ECO:0000269\|PubMed:12105215, ECO:0000269\|PubMed:14699119	1..142		43/135 (32%)
		FHA	27..119	CDD:238017	34/102 (33%)
		WASH_WAHD	<98..>212	CDD:403229	11/53 (21%)
		Interaction with EED. /evidence=ECO:0000269\|PubMed:12788942	143..224		3/8 (38%)
		Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:11034904	185..209
		Involved in PP-1 inhibition	191..200
		Involved in PP-1 binding	200..203
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:11034904	210..240
		Interaction with EED. /evidence=ECO:0000269\|PubMed:12788942	310..329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..351
		RNA-binding	330..351
		Involved in PP-1 inhibition	331..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D955935at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920