DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(f) and cstf3

DIOPT Version :9

Sequence 1:	NP_001015241.3	Gene:	su(f) / 3354994	FlyBaseID:	FBgn0003559	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_998218.2	Gene:	cstf3 / 406326	ZFINID:	ZDB-GENE-040426-1997	Length:	716	Species:	Danio rerio

Alignment Length:	755	Identity:	414/755 - (54%)
Similarity:	548/755 - (72%)	Gaps:	59/755 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EWGMERLVRAQQVVELRPYDIESWSVMIREAQTRPIHEVRSLYESLVNVFPTTARYWKLYIEMEM 77
            |:..|::.:|::.:|..|||:::||::|||||.:||.:.|..||.||..||::.|:||||||.|:
Zfish    12 EYIPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEI 76

  Fly    78 RSRYYERVEKLFQRCLVKILNIDLWKLYLTYVKETKSGLSTHKEKMAQAYDFALEKIGMDLHSFS 142
            :::.|::|||||||||:|:|:|||||.||:||:|||..|.::||||||||||||:||||::.|:.
Zfish    77 KAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQ 141

  Fly   143 IWQDYIYFLRGVEAVGNYAENQKITAVRRVYQKAVVTPIVGIEQLWKDYIAFEQNINPIISEKMS 207
            ||.|||.||:||||||:|||||:|||||||||:..|.|::.|||||:||..:|:.||..:::||.
Zfish   142 IWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYSKYEEGINVHLAKKMI 206

  Fly   208 LERSKDYMNARRVAKELEYHTKGLNRNLPAVPPTLTKEEVKQVELWKRFITYEKSNPLRTEDTAL 272
            .:||:|||||||||||.|...|||:||.|:|||..:.:|.:|||:||::|.:||||||||||..|
Zfish   207 EDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNSPQEAQQVEMWKKYIQWEKSNPLRTEDQTL 271

  Fly   273 VTRRVMFATEQCLLVLTHHPAVWHQASQFLDTSARVLTEKGVRTSVENISPILCVPVVNQIEWVM 337
            :|:|||||.|||||||.|||.:|::|:|:|:.|:::|.|||
Zfish   272 ITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKG------------------------ 312

  Fly   338 AFAWWWAKDVQAAKIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKVHTMYNKLLQL 402
                    |:..||:|:||.|||.||:|..:|.:|.||||::||:||.|:|:||||::||:||.:
Zfish   313 --------DMNNAKLFSDEAANIYERAIGTLLKKNMLLYFSFADYEESRMKHEKVHSIYNRLLAI 369

  Fly   403 PDIDPTLVYVQYMKFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALMEYYCSKDKEIAFRIFE 467
            .||||||||:||||||||||||||.||||||||||.|:|:|::|.||||||||||||.:||:|||
Zfish   370 EDIDPTLVYIQYMKFARRAEGIKSGRSIFKKAREDPRTRHHVYVTAALMEYYCSKDKSVAFKIFE 434

  Fly   468 LGLKRFGGSPEYVMCYIDYLSHLNEDNNTRVLFERVLSSGGLSPHKSVEVWNRFLEFESNIGDLS 532
            ||||::|..|||::.||||||||||||||||||||||:||.|||.||.|:|.|||.||||||||:
Zfish   435 LGLKKYGDIPEYILAYIDYLSHLNEDNNTRVLFERVLTSGSLSPEKSGEIWARFLAFESNIGDLA 499

  Fly   533 SIVKVERRRSAVFENLKEYEGKETAQLVDRYKFLDLYPCTSTELKSIGY-----AENVGIILNKV 592
            ||:||||||...|::  ||||||||.|||||||:|||||:.:|||::||     |:...:|...|
Zfish   500 SILKVERRRFMAFKD--EYEGKETALLVDRYKFMDLYPCSPSELKALGYKDVSRAKYASLIPEAV 562

  Fly   593 GGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAHPGAHPLAGGVFPQPPALAALCATLP 657
                .:.:|..::.:::..|..|:||..|||||:||..|.||.||:.|||||.|||...|...||
Zfish   563 ----VAPSTPALKDEADRKPEYPKPDTCQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLP 623

  Fly   658 PPNSFRGPFVSVELLFDIFMRLNLPDSAPQPNGDNEL-SPKIFDLAKSVHWIVDTSTYTGVQHSV 721
            ||:.|.||||.|:.:.:...|..|||:.   :...|| :.|..:::...:..|:       .|||
Zfish   624 PPSCFTGPFVQVDEMMEALRRCVLPDTV---DAAVELITGKQLEMSSEGNGPVE-------NHSV 678

  Fly   722 TAVPPRRRRLLPGGD-DSDDELQTAVPPSHDIYRLRQLKR 760
            .....:|    |..| |.:::..:..||.|||||.||.||
Zfish   679 ANKSLKR----PNADSDEEEDKGSIAPPIHDIYRARQQKR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(f)	NP_001015241.3	RNA14	19..550	CDD:227438	322/530 (61%)
		HAT	48..78	CDD:214642	16/29 (55%)
		Suf	408..682	CDD:283497	173/278 (62%)
cstf3	NP_998218.2	RNA14	1..515	CDD:227438	324/536 (60%)
		TPR repeat	31..60	CDD:276809	15/28 (54%)
		HAT	45..77	CDD:214642	17/31 (55%)
		TPR repeat	65..92	CDD:276809	16/26 (62%)
		Suf	375..648	CDD:283497	173/278 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583859
Domainoid	1	1.000	455	1.000	Domainoid score	I480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1014
Inparanoid	1	1.050	818	1.000	Inparanoid score	I456
OMA	1	1.010	-	-		QHG57539
OrthoDB	1	1.010	-	-		D217087at33208
OrthoFinder	1	1.000	-	-		FOG0001614
OrthoInspector	1	1.000	-	-		oto39696
orthoMCL	1	0.900	-	-		OOG6_102277
Panther	1	1.100	-	-	LDO	PTHR19980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1162
SonicParanoid	1	1.000	-	-		X1181
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940