DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(f) and cstf3

DIOPT Version :9

Sequence 1:	NP_001015241.3	Gene:	su(f) / 3354994	FlyBaseID:	FBgn0003559	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_989162.1	Gene:	cstf3 / 394769	XenbaseID:	XB-GENE-980297	Length:	718	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	418/770 - (54%)
Similarity:	545/770 - (70%)	Gaps:	88/770 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EWGMERLVRAQQVVELRPYDIESWSVMIREAQTRPIHEVRSLYESLVNVFPTTARYWKLYIEMEM 77
            |:..|::.:|::.:|..|||:::||::|||||.:||.:.|..||.||..||::.|:||||||.|:
Frog    13 EYVPEKVKKAEKKLEDNPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEV 77

  Fly    78 RSRYYERVEKLFQRCLVKILNIDLWKLYLTYVKETKSGLSTHKEKMAQAYDFALEKIGMDLHSFS 142
            :::.|::|||||||||:|:|:|||||.|::||:|||..|.::||||||||||||:||||::.|:.
Frog    78 KAKNYDKVEKLFQRCLMKVLHIDLWKCYVSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQ 142

  Fly   143 IWQDYIYFLRGVEAVGNYAENQKITAVRRVYQKAVVTPIVGIEQLWKDYIAFEQNINPIISEKMS 207
            ||.|||.||:||||||:|||||:|||||||||:..|.|::.|||||:||..:|:.||..:::||.
Frog   143 IWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMI 207

  Fly   208 LERSKDYMNARRVAKELEYHTKGLNRNLPAVPPTLTKEEVKQVELWKRFITYEKSNPLRTEDTAL 272
            .:||:|||||||||||.|...|||:||.|:|||..|.:|.:|||:||::|.:||||||||||..|
Frog   208 EDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVEMWKKYIQWEKSNPLRTEDQTL 272

  Fly   273 VTRRVMFATEQCLLVLTHHPAVWHQASQFLDTSARVLTEKGVRTSVENISPILCVPVVNQIEWVM 337
            :|:|||||.|||||||.|||.:|::|.|:|:.|:::|.|||
Frog   273 ITKRVMFAYEQCLLVLGHHPDIWYEAGQYLEQSSKLLAEKG------------------------ 313

  Fly   338 AFAWWWAKDVQAAKIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKVHTMYNKLLQL 402
                    |:..||:|:||.|||.||:|:.:|.:|.||||||||:||.|:||||.|::||:||.:
Frog   314 --------DMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKTHSIYNRLLAI 370

  Fly   403 PDIDPTLVYVQYMKFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALMEYYCSKDKEIAFRIFE 467
            .||||||||:||||||||||||||.|.||||||||.|:|:|::|.|||||||||||..:||:|||
Frog   371 EDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDPRTRHHVYVTAALMEYYCSKDTSVAFKIFE 435

  Fly   468 LGLKRFGGSPEYVMCYIDYLSHLNEDNNTRVLFERVLSSGGLSPHKSVEVWNRFLEFESNIGDLS 532
            ||||::|..||||:.||||||||||||||||||||||:||.|.|.||.|:|.|||.||||||||:
Frog   436 LGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLA 500

  Fly   533 SIVKVERRRSAVFENLKEYEGKETAQLVDRYKFLDLYPCTSTELKSIGY-----AENVGIILNKV 592
            ||:|||:||...|:  :||||||||.|||||||:|||||:::|||::||     |:...:|.:.|
Frog   501 SILKVEKRRYTAFK--EEYEGKETALLVDRYKFMDLYPCSTSELKALGYKDVSRAKLAALIPDPV 563

  Fly   593 GGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAHPGAHPLAGGVFPQPPALAALCATLP 657
            ...:.:.:   ::.|.:..|..|:||.||||||:||..|.||.||:.|||||.|||...|...||
Frog   564 IAPSIAPS---LKDDVDRKPEYPKPDTSQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVILMKLLP 625

  Fly   658 PPNSFRGPFVSVELLFDIFMRLNLPDSAPQP---------------NGDNELSPKIFDLAKSVHW 707
            ||..|:||||.|:.:.:|..|..|||:..:.               ||..|::..   |.|||
Frog   626 PPICFQGPFVQVDEIMEILRRCKLPDTVEEAVRIITGSQAEMNMEGNGPVEVNTL---LNKSV-- 685

  Fly   708 IVDTSTYTGVQHSVTAVPPRRRRLLPGGDDSDDELQ--TAVPPSHDIYRLRQLKR 760
                                 :|   ..:|||||.:  :.|||.|||||.||.||
Frog   686 ---------------------KR---PNEDSDDEEEKGSVVPPVHDIYRTRQQKR 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(f)	NP_001015241.3	RNA14	19..550	CDD:227438	321/530 (61%)
		HAT	48..78	CDD:214642	16/29 (55%)
		Suf	408..682	CDD:283497	172/278 (62%)
cstf3	NP_989162.1	RNA14	8..533	CDD:227438	338/553 (61%)
		TPR repeat	32..61	CDD:276809	15/28 (54%)
		HAT	46..78	CDD:214642	17/31 (55%)
		TPR repeat	66..93	CDD:276809	16/26 (62%)
		Suf	376..650	CDD:283497	172/278 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I482
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1014
Inparanoid	1	1.050	816	1.000	Inparanoid score	I467
OMA	1	1.010	-	-		QHG57539
OrthoDB	1	1.010	-	-		D217087at33208
OrthoFinder	1	1.000	-	-		FOG0001614
OrthoInspector	1	1.000	-	-		otm47613
Panther	1	1.100	-	-	O	PTHR19980
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080