DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(f) and suf-1

DIOPT Version :9

Sequence 1:	NP_001015241.3	Gene:	su(f) / 3354994	FlyBaseID:	FBgn0003559	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_495825.1	Gene:	suf-1 / 174380	WormBaseID:	WBGene00006307	Length:	735	Species:	Caenorhabditis elegans

Alignment Length:	768	Identity:	342/768 - (44%)
Similarity:	482/768 - (62%)	Gaps:	80/768 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VELRPYDIESWSVMIREAQTRPIHEVRSLYESLVNVFPTTARYWKLYIEMEMRSRYYERVEKLFQ 90
            :|..|:|:::|::::||.|:|||.:.|..|||||..||.:.||||.|||.|:||:.:|.|||||.
Worm    13 IETNPFDVDAWNLLLREHQSRPIDQERDFYESLVKQFPNSGRYWKAYIEHELRSKNFENVEKLFS 77

  Fly    91 RCLVKILNIDLWKLYLTYVKETKSGLSTHKEKMAQAYDFALEKIGMDLHSFSIWQDYIYFLRGVE 155
            ||||.:|||||||.|:.||.|||.....::|:||:||||||||:|||:.::||:.:||.||:.|.
Worm    78 RCLVSVLNIDLWKCYIHYVFETKGQRDQYREEMAKAYDFALEKVGMDVQAYSIFTEYIAFLKKVP 142

  Fly   156 AVGNYAENQKITAVRRVYQKAVVTPIVGIEQLWKDYIAFEQNINPIISEKMSLERSKDYMNARRV 220
            |||.|||||:|||||::||||:.||:..:|.:|.||..:|:.||..::||:..||.|:|.|||||
Worm   143 AVGQYAENQRITAVRKIYQKALATPMHNLELIWNDYCTYEKAINITLAEKLIAERGKEYQNARRV 207

  Fly   221 AKELEYHTKGLNRNLPAVPPTLTKEEVKQVELWKRFITYEKSNPLRTEDTALVTRRVMFATEQCL 285
            .|:|:..|:||||...:|||..|..|.|||||||..|.:||:|||:||:.....|||::..||.|
Worm   208 EKDLQQMTRGLNRQAVSVPPKGTATEFKQVELWKNLIAWEKTNPLQTEEYGQHARRVVYTYEQSL 272

  Fly   286 LVLTHHPAVWHQASQFLDTSARVLTEKGVRTSVENISPILCVPVVNQIEWVMAFAWWWAKDVQAA 350
            |.|.::|.:|::|:.||..::..|.|||                                ||:.|
Worm   273 LCLGYYPDIWYEAAMFLQEASHTLDEKG--------------------------------DVKMA 305

  Fly   351 KIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKVHTMYNKLLQLPDIDPTLVYVQYM 415
            ::...|..::.||:|.|::..:.|||||||||:|...::|.|..:|::||.:..|:|||.|||.|
Worm   306 QVLKLETISLYERAITGLMKESKLLYFAYADFQEEHKQFEAVKNIYDRLLGIEHINPTLTYVQLM 370

  Fly   416 KFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALMEYYCSKDKEIAFRIFELGLKRFGGSPEYV 480
            :|.||:||..:||.:||:||||.|:.|.:||||||:||.|.||||:|.|:|:||||::...||:.
Worm   371 RFIRRSEGPNNARLVFKRAREDKRTGYQVFVAAALLEYNCMKDKEVAIRVFKLGLKKYENEPEFG 435

  Fly   481 MCYIDYLSHLNEDNNTRVLFERVLSSGGLSPHKSVEVWNRFLEFESNIGDLSSIVKVERRRSAVF 545
            :.|.|:||:|||||||||:|||:|:|..|...||:.:|:|||:|||.:|||:||:|||:||...:
Worm   436 LAYADFLSNLNEDNNTRVVFERILTSSKLPADKSIRIWDRFLDFESCVGDLASILKVEKRRKTAY 500

  Fly   546 ENLKEYEGKETAQLV-DRYKFLDLYPCTSTELKSIGY----------------AENV-------- 585
            |..::.:....:.|| |||||:||.||:..:||.|||                ::||
Worm   501 EEAQKDQTMNHSMLVIDRYKFMDLMPCSGEQLKLIGYNALKGTESIAGPSFVGSKNVPTHGPQAA 565

  Fly   586 GIILNKVGGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAHPGAHPLAGGVFPQPPALA 650
            ..|:...||.|.....|           .||||.|||||||||.......||:.|||||.|.::|
Worm   566 SAIMGGAGGHADVARYG-----------FPRPDISQMIPFKPRVNCTASFHPVPGGVFPPPQSVA 619

  Fly   651 ALCATLPPPNSFRGPFVSVELLFDIFMRLNLPDSAPQPNGDNELSPKI-FDLAKSVHWIV-DTST 713
            .|.:.||||..|.|||::||||.::...:.||:.:...:.||.|.|.: .|:.|.::.:: .||.
Worm   620 HLMSLLPPPTCFIGPFINVELLCNMINNMQLPNVSYPKSEDNMLGPMLEQDVKKDMYQLLATTSD 684

  Fly   714 YTGVQHSVTAVPPRRRRLLPGGDDSDDE----LQTAVPP--SHDIYRLRQLKR 760
            .:.|..|......:|:|    ||..|:|    |...:..  |.|.|:.|..|:
Worm   685 PSAVVRSSALSDLKRKR----GDSDDEEDYSHLGAVIGSLGSRDAYKRRMNKK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(f)	NP_001015241.3	RNA14	19..550	CDD:227438	260/523 (50%)
		HAT	48..78	CDD:214642	17/29 (59%)
		Suf	408..682	CDD:283497	140/298 (47%)
suf-1	NP_495825.1	RNA14	12..502	CDD:227438	259/520 (50%)
suf-1	NP_495825.1	Suf	363..651	CDD:368636	140/298 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161129
Domainoid	1	1.000	366	1.000	Domainoid score	I487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1014
Inparanoid	1	1.050	642	1.000	Inparanoid score	I440
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57539
OrthoDB	1	1.010	-	-		D217087at33208
OrthoFinder	1	1.000	-	-		FOG0001614
OrthoInspector	1	1.000	-	-		oto19163
orthoMCL	1	0.900	-	-		OOG6_102277
Panther	1	1.100	-	-	LDO	PTHR19980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1162
SonicParanoid	1	1.000	-	-		X1181
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940