DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(f) and CSTF3

DIOPT Version :9

Sequence 1:	NP_001015241.3	Gene:	su(f) / 3354994	FlyBaseID:	FBgn0003559	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001317.1	Gene:	CSTF3 / 1479	HGNCID:	2485	Length:	717	Species:	Homo sapiens

Alignment Length:	759	Identity:	417/759 - (54%)
Similarity:	542/759 - (71%)	Gaps:	66/759 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EWGMERLVRAQQVVELRPYDIESWSVMIREAQTRPIHEVRSLYESLVNVFPTTARYWKLYIEMEM 77
            |:..|::.:|::.:|..|||:::||::|||||.:||.:.|..||.||..||::.|:||||||.|:
Human    12 EYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEI 76

  Fly    78 RSRYYERVEKLFQRCLVKILNIDLWKLYLTYVKETKSGLSTHKEKMAQAYDFALEKIGMDLHSFS 142
            :::.|::|||||||||:|:|:|||||.||:||:|||..|.::||||||||||||:||||::.|:.
Human    77 KAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQ 141

  Fly   143 IWQDYIYFLRGVEAVGNYAENQKITAVRRVYQKAVVTPIVGIEQLWKDYIAFEQNINPIISEKMS 207
            ||.|||.||:||||||:|||||:|||||||||:..|.|::.|||||:||..:|:.||..:::||.
Human   142 IWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMI 206

  Fly   208 LERSKDYMNARRVAKELEYHTKGLNRNLPAVPPTLTKEEVKQVELWKRFITYEKSNPLRTEDTAL 272
            .:||:|||||||||||.|...|||:||.|:|||..|.:|.:||::||::|.:||||||||||..|
Human   207 EDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTL 271

  Fly   273 VTRRVMFATEQCLLVLTHHPAVWHQASQFLDTSARVLTEKGVRTSVENISPILCVPVVNQIEWVM 337
            :|:|||||.|||||||.|||.:|::|:|:|:.|:::|.|||
Human   272 ITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKG------------------------ 312

  Fly   338 AFAWWWAKDVQAAKIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKVHTMYNKLLQL 402
                    |:..||:|:||.|||.||:|:.:|.:|.||||||||:||.|:||||||::||:||.:
Human   313 --------DMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAI 369

  Fly   403 PDIDPTLVYVQYMKFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALMEYYCSKDKEIAFRIFE 467
            .||||||||:||||||||||||||.|.||||||||.|:|:|::|.||||||||||||.:||:|||
Human   370 EDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFE 434

  Fly   468 LGLKRFGGSPEYVMCYIDYLSHLNEDNNTRVLFERVLSSGGLSPHKSVEVWNRFLEFESNIGDLS 532
            ||||::|..||||:.||||||||||||||||||||||:||.|.|.||.|:|.|||.||||||||:
Human   435 LGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLA 499

  Fly   533 SIVKVERRRSAVFENLKEYEGKETAQLVDRYKFLDLYPCTSTELKSIGY-----AENVGIILNKV 592
            ||:|||:||...|:  :||||||||.|||||||:|||||:::|||::||     |:...||.:.|
Human   500 SILKVEKRRFTAFK--EEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPV 562

  Fly   593 GGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAHPGAHPLAGGVFPQPPALAALCATLP 657
               ........::.:.:..|..|:||..|||||:||..|.||.||:.|||||.|||...|...||
Human   563 ---VAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLP 624

  Fly   658 PPNSFRGPFVSVELLFDIFMRLNLPDSAPQ-----PNGDNELSPKIFDLAKSVHWIVDTSTYTGV 717
            ||..|:||||.|:.|.:||.|..:|::..:     ..|..||:.:                ..|.
Human   625 PPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVE----------------GNGP 673

  Fly   718 QHSVTAVPPRRRRLLPGGD-DSDDELQTAVPPSHDIYRLRQLKR 760
            ..|...:....:|  |..| |.|:|....|||.|||||.||.||
Human   674 VESNAVLTKAVKR--PNEDSDEDEEKGAVVPPVHDIYRARQQKR 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(f)	NP_001015241.3	RNA14	19..550	CDD:227438	323/530 (61%)
		HAT	48..78	CDD:214642	16/29 (55%)
		Suf	408..682	CDD:283497	174/278 (63%)
CSTF3	NP_001317.1	RNA14	14..515	CDD:227438	324/534 (61%)
		TPR repeat	31..60	CDD:276809	15/28 (54%)
		HAT 1	45..77		17/31 (55%)
		TPR repeat	65..92	CDD:276809	16/26 (62%)
		HAT 2	79..110		21/30 (70%)
		HAT 3	117..152		24/34 (71%)
		HAT 4	163..196		20/32 (63%)
		HAT 5	221..261		20/39 (51%)
		HAT 6	271..303		21/31 (68%)
		HAT 7	319..352		20/32 (63%)
		HAT 8	354..387		24/32 (75%)
		Suf	375..649	CDD:399092	174/278 (63%)
		HAT 9	458..494		27/35 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..705		9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149720
Domainoid	1	1.000	461	1.000	Domainoid score	I485
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1014
Inparanoid	1	1.050	819	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57539
OrthoDB	1	1.010	-	-		D217087at33208
OrthoFinder	1	1.000	-	-		FOG0001614
OrthoInspector	1	1.000	-	-		oto88591
orthoMCL	1	0.900	-	-		OOG6_102277
Panther	1	1.100	-	-	LDO	PTHR19980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1162
SonicParanoid	1	1.000	-	-		X1181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940