Protein Alignment zyd and Slc24a3

DIOPT Version :9

• Sequence 1: NP_001015261.3
• Gene: zyd / 3354992
• FlyBaseID: FBgn0265767
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_001343426.1
• Gene: Slc24a3 / 94249
• MGIID: 2137513
• Length: 645
• Species: Mus musculus
• Alignment Length: 582
• Identity: 234/582 - (40%)
• Similarity: 326/582 - (56%)
• Gaps: 84/582 - (14%)

  Fly    21 NCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVA 85
            |||:||:.:||||:||...|:.|||||||:.::|:|.|||:|||::|||::||||..|::|.|||
Mouse    85 NCTEPALHEFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVA 149

  Fly    86 GATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTR 150
            |||||||.:||||||.:|||.|||:||:||||||||||||||.:...||:.||..:.|..|.|.|
Mouse   150 GATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLR 214

  Fly   151 DSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKC----AKG------GVK 205
            |||.|.::|..||..::||:|.|:|:|:||.:|.:|:.:|.::....:|    .||      |:.
Mouse   215 DSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLA 279

  Fly   206 QARSRSRSSNC----------SIHTKNSNEKEPELV------------------------ENRIC 236
            .......||||          :.|.|.|.....||:                        :.|:
Mouse   280 NNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRL- 343

  Fly   237 QNMANIQLNGGLNKEQAKATS---TSGAGTTAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGA 298
             :||:..|   :|:.|....|   |:|....||.|...         |:...|   .|..|.|..
Mouse   344 -SMASRML---INERQRLINSRAYTNGESEVAIKIPIK---------HTVENG---TGPSSAPDR 392

  Fly   299 IVQMAPLDDAEAESHVAVAAADEGRK--------------EEG-YSLLSYPKDKSCFAQFTWLII 348
            .|.....||..||:.......:|..:              :|| |:....|..|  .....|...
Mouse   393 GVNGTRRDDIVAETDNETENENEDNENNENDEEEEEDEDDDEGPYTPFDPPSGK--LETVKWAFT 455

  Fly   349 WPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLA 413
            ||:..:....:|:|.|....|.|.:||....:||.:.||::.||:||||.||.|||.:|||||||
Mouse   456 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLA 520

  Fly   414 AGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPGQNYVAINSAG 478
            ||||||:.::|:|||::|.|.|.:.||||||.||||:.||:||.::.:  .:..| :|:.:||.|
Mouse   521 AGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTL--AVDYG-SYIRLNSRG 582

  Fly   479 LEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIELNVFFRVNLPTCG 540
            |.||...||:::|:.......||::||||:|..||.:|.||:.|:.:.|.|||..||||.||
Mouse   583 LIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMTEFNVFTFVNLPMCG 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	208/537 (39%)
		Na_Ca_ex	48..192	CDD:279963	83/143 (58%)
		Na_Ca_ex	370..525	CDD:279963	76/154 (49%)
Slc24a3	NP_001343426.1	Na_Ca_ex	<89..631	CDD:332332	221/563 (39%)
		Alpha-1	148..188		32/39 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..398		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..442		6/37 (16%)
		Alpha-2	520..551		18/30 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41390
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1802
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50092
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103920
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X1463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.830