DRSC/TRiP Functional Genomics Resources

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Protein Alignment zyd and SLC24A1

DIOPT Version :9

Sequence 1:NP_001015261.3 Gene:zyd / 3354992 FlyBaseID:FBgn0265767 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_004718.1 Gene:SLC24A1 / 9187 HGNCID:10975 Length:1099 Species:Homo sapiens


Alignment Length:668 Identity:191/668 - (28%)
Similarity:304/668 - (45%) Gaps:172/668 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PAIDD------FPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSND 83
            |::.|      :|.||||..:|:.|.|||||...:|:|||||:|||||||||:..|...|.:|.|
Human   429 PSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISED 493

  Fly    84 VAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPL 148
            |||||||||..||||||.::||.||:..::|:||||||||||||.|...|.:.:...:.|.||||
Human   494 VAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558

  Fly   149 TRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDK------------------- 194
            .||...|.:.:.:||....|..:.|:|:|:|:..||.|:..|.::|                   
Human   559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVM 623

  Fly   195 TFQKCAKGG-----VKQARSRSR----------SSNCSIHTKNSNEKEPELV--------ENRIC 236
            ..:..:|.|     |.:.:...:          ||:.|:|.........:|:        |.|:.
Human   624 ALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLA 688

  Fly   237 QNMANIQLNGGLNKE-QAKATS----TSGAGTTAISITTSTM-------------TTTLSTTHSA 283
            :......||.|...: ||||.|    ...|...|:::|.:.:             ...::...|.
Human   689 KEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAEST 753

  Fly   284 GGGGGAVGLCSGPGAIVQMA-----------------------------------------PLDD 307
            |...|..|..:|.|...:.:                                         ..:|
Human   754 GEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAED 818

  Fly   308 AE--------------AESHVAVAAADEGRKEEGYS----------------------------- 329
            .|              ||:|......::|.::.|.|                             
Human   819 GEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEE 883

  Fly   330 --------------LLSYPKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIV 380
                          .|.:|:.:.  .|..:|.:.||.....:.:||.::.::.|.|..||:..|:
Human   884 EEEEEEEKGNEEPLSLDWPETRQ--KQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIM 946

  Fly   381 WIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNT 445
            ||...||::.|....:|:|:.|.:.:||:|.||||||:|:.::|||||::|.|.|.:.:|:|||.
Human   947 WIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 1011

  Fly   446 FDILLCLGVPWLIKAVFFPIQPGQNYVAINSAGLEYSAITLLSTLFLLYL-TFSTNKFKLDKKVG 509
            |||.:.|.||||:.::...:||    |.::|.|| :.||.||..:.|..: :.::.|::::|.:|
Human  1012 FDITVGLPVPWLLFSLINGLQP----VPVSSNGL-FCAIVLLFLMLLFVISSIASCKWRMNKILG 1071

  Fly   510 TACLVMYLVFMVFASLIE 527
            ....::|.||::.:.::|
Human  1072 FTMFLLYFVFLIISVMLE 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zydNP_001015261.3 ECM27 46..522 CDD:223604 180/634 (28%)
Na_Ca_ex 48..192 CDD:279963 74/143 (52%)
Na_Ca_ex 370..525 CDD:279963 59/155 (38%)
SLC24A1NP_004718.1 2A1904 1..1099 CDD:273344 191/668 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 123..150
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..199
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..304
Alpha-1 494..534 27/39 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 690..901 26/210 (12%)
Alpha-2 979..1010 16/30 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0530
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1168500at2759
OrthoFinder 1 1.000 - - FOG0000196
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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