DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and YDL206W

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_010075.1	Gene:	YDL206W / 851321	SGDID:	S000002365	Length:	762	Species:	Saccharomyces cerevisiae

Alignment Length:	779	Identity:	129/779 - (16%)
Similarity:	243/779 - (31%)	Gaps:	293/779 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ISHILLFCYINCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKIC 75
            :|:::|..|...:..:|.:|               .||.:..:..|..|.||..:...|::..|.
Yeast    15 VSNVILIGYSLSSNGSISEF---------------YLHSVVLIECFSLLGVVTSDCLTPSLSYIS 64

  Fly    76 AAL-NMSNDVAGATFMAAATSAPELFVNVIGTF--ITEG--DIGVGTIVGSAVFNILAVAACCGI 135
            :.: ::|:.|:|.|.:|...:.|:    :..|:  :..|  .:.:|.:.|...|.:..|....|.
Yeast    65 SNIFHISDRVSGMTLLALGNALPD----ITSTYQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGC 125

  Fly   136 GAGMTIPLDW-----------WPLTRDSIAYGVTVAILICV-------MHDERVEWYEALILVSL 182
            .|.:....|.           ..|:.|...|.:.|.|...:       :.|.|:.::|.:::|..
Yeast   126 VATIQFQHDKSIETYTEESFDQNLSYDRSNYILDVGIFTFMLLVSGTFLADGRLYFWECIVMVLT 190

  Fly   183 Y---AVYLAVMY---------------FDKTFQ-------------------KCAKGGVKQAR-- 208
            |   ||||...|               ..||..                   .....|::..|
Yeast   191 YCCCAVYLIKSYKYPCEINDALEREVEIKKTVLANNHITVPNRFTLTTTSDITSTDDGIRYVRPL 255

  Fly   209 -------------SRSRSSNCSI-HTKNSNEKEPE---LVENRI---------------CQNMAN 241
                         ..:|..:.|: :....|:..||   |:..||               .|::.|
Yeast   256 GDTQIDEDNAISLDPTRLPSKSLDNISRFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDLLN 320

  Fly   242 IQLNGGLNKEQAKATS--------------------------------------------TSGAG 262
            |.....|.....|:.|                                            .|.|.
Yeast   321 IWEKQNLFNNTVKSLSLPSDDTHLFTKASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNAL 385

  Fly   263 TTAIS--------------------------------------------ITTSTMTTTLSTTHSA 283
            .||||                                            |.....|.|..:|::.
Yeast   386 DTAISAPQNEYQTYYNEPTSLFLTVPQKKTSKKSLSCDRIPNLVRSNNIILNDEATRTQESTNAL 450

  Fly   284 GGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGYSLLSYPKDKSC---FAQF-T 344
            ......:     ..:::|. ..||...:..:::.:.........:.|.:|..|.|.   |.:| :
Yeast   451 NSISDVI-----DNSLLQY-ERDDIILDRTLSLCSTKSRTAWHSFQLYNYLTDVSLEIGFFEFLS 509

  Fly   345 WLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCI------------------VWIGSLSYVVAW 391
            .|:..|:.::..::||. :.::.:...||:::..|                  .|:..||.|:|.
Yeast   510 LLVTTPVSIILYLSIPS-EISQTDHDLPLSYLQNIQLIASPIILNQLITNNFSFWLLILSLVIAI 573

  Fly   392 M--------------------------------ITIIGDTL-------KIPDSVMGITFLAAGTS 417
            :                                :.||..||       .|.::::|:|....|.|
Yeast   574 LLYFKTRTIPNKFNSDIIFTVAFLLSLACLSKAVHIIVVTLTHWINVFNISETILGLTIFTWGNS 638

  Fly   418 VPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPGQNYVAINSAGLEYS 482
            :.:.||::...|.|...:.|....||.....|..:|...::      |..|.....|.| |.:.:
Yeast   639 IGDLVSNITFVKIGVLEIAIGACFGSPLLYFLFGVGFDGIM------IMLGDKTGKIVS-GRDSN 696

  Fly   483 AI----------TLLST---LFLLYLTFST----NKFKLDKKVGTACLVMYLVFMVFASLIELN 529
            .:          .|::|   :.:.:|.|:.    |.:|:|||:..|.|.:|:|....:..:|::
Yeast   697 ILMHHIDFKVDKNLINTGVGILIAFLIFTVLIPLNDWKIDKKISIALLTLYIVVTCISVFLEVH 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	123/735 (17%)
		Na_Ca_ex	48..192	CDD:279963	37/184 (20%)
		Na_Ca_ex	370..525	CDD:279963	44/228 (19%)
YDL206W	NP_010075.1	ECM27	28..>223	CDD:223604	42/213 (20%)
YDL206W	NP_010075.1	ECM27	<543..757	CDD:223604	42/220 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	94	1.000	Inparanoid score	I1510
Isobase	1	0.950	-	0	Normalized mean entropy	S2929
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840