DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and Slc24a2

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_113931.1	Gene:	Slc24a2 / 84550	RGDID:	628650	Length:	670	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	188/586 - (32%)
Similarity:	289/586 - (49%)	Gaps:	116/586 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVA 85
            |.|..|..|:|:|:||..:|:.||::||||..:|:|:|||:||||:|||::..|...|.:|:|||
  Rat   112 NGTDHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVA 176

  Fly    86 GATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTR 150
            |||||||..||||||.::||.||...::|:||||||||||||.|...|.:.:...:.|.||||.|
  Rat   177 GATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR 241

  Fly   151 DSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQ----------KCAKGGVK 205
            |...|.|.:.:||....|..:.|:|:|:|::.|..|:..|.|:...:          |..|..|.
  Rat   242 DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVS 306

  Fly   206 QARSRSRS-------------------SNCSIH-------------------------------- 219
            :|::::.:                   |:.|:|
  Rat   307 EAQAKASTAGDKEEPTLPNKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYY 371

  Fly   220 ---TKNSNEKEPELVENRI----CQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTL 277
               |:....:|...:.::|    ||...|.:.||..|.....|..        |.:..||.|.
  Rat   372 DTMTEEGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEK--------IELPNSTSTE-- 426

  Fly   278 STTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAE------SHVAVAAAD-----EGRKEEGYSLL 331
                                  |:|.|..:|...      || ::.|||     |..:|:....|
  Rat   427 ----------------------VEMTPSSEASEPVQNGNLSH-SIEAADAPQATETAEEDDDQPL 468

  Fly   332 SYPKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITII 396
            |.....:...|.|:||:.||.....|.:||.:|..:.|.||:||...|.||...||::.|....:
  Rat   469 SLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQV 533

  Fly   397 GDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAV 461
            |:|:.|.:.:||:|.||||||:|:.::|||||::|.|.|.:.:|:|||.|||.:.|.:|||:..:
  Rat   534 GETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTI 598

  Fly   462 FFPIQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLI 526
            ....:|    |.::|.||..:.:.|...|..:.|:.:..|::::|.:|.....:|..|:|.:.|:
  Rat   599 IHRFKP----VTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSVLL 659

  Fly   527 E 527
            |
  Rat   660 E 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	174/554 (31%)
		Na_Ca_ex	48..192	CDD:279963	72/143 (50%)
		Na_Ca_ex	370..525	CDD:279963	56/154 (36%)
Slc24a2	NP_113931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		4/9 (44%)
		TIGR00367	138..652	CDD:273039	173/550 (31%)
		Na_Ca_ex	139..281	CDD:279963	71/141 (50%)
		Alpha-1	175..215		27/39 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		0/22 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..414		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..471		7/20 (35%)
		Na_Ca_ex	507..658	CDD:279963	56/154 (36%)
		Alpha-2	550..581		16/30 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820