Protein Alignment zyd and SLC24A3

DIOPT Version :9

• Sequence 1: NP_001015261.3
• Gene: zyd / 3354992
• FlyBaseID: FBgn0265767
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_065740.2
• Gene: SLC24A3 / 57419
• HGNCID: 10977
• Length: 644
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 235/596 - (39%)
• Similarity: 329/596 - (55%)
• Gaps: 93/596 - (15%)

  Fly     4 IRNMKSSISHILLFCYINCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFV 68
            :||.|            |||:||:.:||.|:|:...|:.|||||||:.::|:|.|||:|||::||
Human    81 LRNSK------------NCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFV 133

  Fly    69 PAVEKICAALNMSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACC 133
            |::||||..|::|.||||||||||.:||||||.:|||.|||:||:||||||||||||||.:...|
Human   134 PSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVC 198

  Fly   134 GIGAGMTIPLDWWPLTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQK 198
            |:.||..:.|..|.|.||||.|.::|..||..::||:|.|:|:|:||.:|.:|:.:|.::....:
Human   199 GLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQ 263

  Fly   199 C----AKG------GVKQARSRSRSSNC----------SIHTKNSNEKEPELV------------ 231
            |    .||      |:........||||          :.|.|.|.....||:
Human   264 CFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEA 328

  Fly   232 ------------ENRICQNMANIQLNGGLNKEQAKATS---TSGAGTTAISITTSTMTTTLSTTH 281
                        :.|:  :||:..|   :|:.|....|   |:|....||.|...         |
Human   329 GLRIMITSHFPPKTRL--SMASRML---INERQRLINSRAYTNGESEVAIKIPIK---------H 379

  Fly   282 SAGGGGGAVGLCSGPGAIVQMAPLDDAEAES------------HVAVAAADEGRKEEGYSLLSYP 334
            :...|   .|..|.|...|.....||..||:            :......||...|..|:....|
Human   380 TVENG---TGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTP 441

  Fly   335 KDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDT 399
            ..|  .....|...||:..:....:|:|.|.:..|.|.:||....:||.:.||::.||:||||.|
Human   442 SGK--LETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYT 504

  Fly   400 LKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFP 464
            |.|||.:|||||||||||||:.::|:|||::|.|.|.:.||||||.||||:.||:||.::.:  .
Human   505 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTL--A 567

  Fly   465 IQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIELN 529
            :..| :|:.:||.||.||...||:::|:.......||::||||:|..||::|.||:.|:.:.|.|
Human   568 VDYG-SYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFN 631

  Fly   530 VFFRVNLPTCG 540
            ||..||||.||
Human   632 VFTFVNLPMCG 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	208/534 (39%)
		Na_Ca_ex	48..192	CDD:279963	83/143 (58%)
		Na_Ca_ex	370..525	CDD:279963	76/154 (49%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	197/514 (38%)
		Na_Ca_ex	113..255	CDD:279963	82/141 (58%)
		Alpha-1	149..189		32/39 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..442		6/36 (17%)
		Na_Ca_ex	475..627	CDD:279963	76/154 (49%)
		Alpha-2	518..549		18/30 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41390
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1823
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50092
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103920
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X1463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.840