DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and slc24a5

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001025451.1	Gene:	slc24a5 / 570312	ZFINID:	ZDB-GENE-031210-1	Length:	513	Species:	Danio rerio

Alignment Length:	530	Identity:	180/530 - (33%)
Similarity:	281/530 - (53%)	Gaps:	88/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVAG 86
            |.||...:||...|:..:|:.|.::::.:...|:.:::::||||||:|::|.|...|.:|.||||
Zfish    58 CVQPQSSEFPEGFFTVQERKDGGILIYFMIIFYMLLSVSIVCDEYFLPSLEVISERLGLSQDVAG 122

  Fly    87 ATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRD 151
            ||||||.:|||||....:|.|:|:|||||.||:||||:|:|.:.|.||:.:.....|..|||.||
Zfish   123 ATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIMGSAVYNLLCICAACGLLSSAVGRLSCWPLFRD 187

  Fly   152 SIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKCAKGGVKQARSRSRSSNC 216
            .:||.::||.:|.::.|.||.||:...|:.:|.||:||:.||....:..         ..|.|.|
Zfish   188 CVAYAISVAAVIAIISDNRVYWYDGACLLLVYGVYVAVLCFDLRISEYV---------MQRFSPC 243

  Fly   217 ----SIHTKNSNEKEPELVENRICQNMANIQLNGGLN----KEQAKATSTSGAGTTAISITTSTM 273
                ....::|.|::|               |.|..:    :.|.::.:.||.
Zfish   244 CWCLKPRDRDSGEQQP---------------LVGWSDDSSLRVQRRSRNDSGI------------ 281

  Fly   274 TTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKE---EGYSLLSYPK 335
                                           ..|....||::::.  .|..|   |..|:.|.|.
Zfish   282 -------------------------------FQDDSGYSHLSLSL--HGLNEISDEHKSVFSMPD 313

  Fly   336 DKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTL 400
            ..  ..:..|::..|:..|..:::|||::......:.|||:|..|||.:.:||:.||:||:|:||
Zfish   314 HD--LKRILWVLSLPVSTLLFVSVPDCRRPFWKNFYMLTFLMSAVWISAFTYVLVWMVTIVGETL 376

  Fly   401 KIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPI 465
            .|||:|||:|.||||||:|:.|:||:||:.|...|.:.|.:|||.|| :||||:||.|:.||..:
Zfish   377 GIPDTVMGMTLLAAGTSIPDTVASVMVAREGKSDMAMSNIVGSNVFD-MLCLGLPWFIQTVFVDV 440

  Fly   466 -QPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIELN 529
             .|    |.:||:||.:.:.|||.::..|:|....|.:||:.|:|..||..|::|...:.|.||.
Zfish   441 GSP----VEVNSSGLVFMSCTLLLSIIFLFLAVHINGWKLNWKLGLVCLACYILFATLSILYELG 501

  Fly   530 VFFRVNLPTC 539
            :.....:.:|
Zfish   502 IIGNNPIRSC 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	168/487 (34%)
		Na_Ca_ex	48..192	CDD:279963	68/143 (48%)
		Na_Ca_ex	370..525	CDD:279963	72/155 (46%)
slc24a5	NP_001025451.1	ECM27	81..497	CDD:223604	168/491 (34%)
		Na_Ca_ex	84..228	CDD:279963	68/143 (48%)
		Na_Ca_ex	346..497	CDD:279963	72/155 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920