DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and slc24a4a

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_005158898.1	Gene:	slc24a4a / 550467	ZFINID:	ZDB-GENE-050417-291	Length:	621	Species:	Danio rerio

Alignment Length:	552	Identity:	217/552 - (39%)
Similarity:	311/552 - (56%)	Gaps:	61/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVA 85
            |||.|||.:||.|||:..||..|||:||:.|:||:|:|||:|||:|||.::||||..|::|.|||
Zfish    93 NCTAPAIHEFPEDLFTNQQRSQGAVLLHIFAALYMFLALAIVCDDYFVTSLEKICEKLHLSEDVA 157

  Fly    86 GATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTR 150
            |||||||.:||||||.::||.|||.||:||||||||||||||.:...|||.||..:.|..:.:.|
Zfish   158 GATFMAAGSSAPELFASIIGVFITHGDVGVGTIVGSAVFNILCIIGVCGIFAGQVVFLTKYAVFR 222

  Fly   151 DSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKCAKGGVKQARSRSRSSN 215
            ||..|.::|..||..::|:.:.|:|:|:|:.:|..|:.||.|:.:.|....|   :...|..:.|
Zfish   223 DSSYYIISVIALIVFIYDDEILWWESLVLIVMYLGYIIVMKFNTSLQNLFNG---KEDKRVTNGN 284

  Fly   216 CSIHTKNSNEKEP------------------ELVENRICQNMANIQLNGGLNKE----------- 251
            ..     |:|.||                  .:..|:|....:.:.::..:|..
Zfish   285 AV-----SSEMEPGNDCFEQFWDDPSWPLLAPVKPNKIYTRGSVVMVDEMMNSSPPHYRFPEAGL 344

  Fly   252 QAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAV 316
            :...|:..|..|.....:...:........||.|              |....:.|.:|::....
Zfish   345 RVMITNHFGPKTRLRMASRLIINEQQRLVKSANG--------------VDSVLVSDQKADTMENG 395

  Fly   317 AAADEGRKEEGYSLLS-YPKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIV 380
            ..|::...||..:.:| :...:.......:.|.|||.||....||:|.|.:....|.|:|.:..|
Zfish   396 NVAEDKLSEEQENEISPFRLPEGAMDTVKFFISWPISLLLYFTIPNCAKKRWECCFMLSFFLSTV 460

  Fly   381 WIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNT 445
            ||.:.||::.||:||:|.||.|||.:|||||||||||||:.::|:|||::|.|.|.:.|:||||.
Zfish   461 WIAAFSYILVWMVTIVGYTLGIPDVIMGITFLAAGTSVPDCIASLIVARQGLGDMAVSNTIGSNV 525

  Fly   446 FDILLCLGVPWLIKAVFFPIQPGQNY---VAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKK 507
            ||||:.|||||.|:.:      ..||   |.|||.||.||.:.||.::.|..|....|:::||.:
Zfish   526 FDILVGLGVPWGIQTM------AVNYGSVVKINSRGLVYSVVLLLGSVALTVLGIHVNRWRLDLR 584

  Fly   508 VGTACLVMYLVFMVFASLIELNVFFRVNLPTC 539
            :|...||:|.:|:.|:.:||.|||..||||.|
Zfish   585 LGIYVLVLYAIFLTFSIMIEYNVFTFVNLPMC 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	190/508 (37%)
		Na_Ca_ex	48..192	CDD:279963	79/143 (55%)
		Na_Ca_ex	370..525	CDD:279963	76/157 (48%)
slc24a4a	XP_005158898.1	TIGR00367	119..596	CDD:273039	189/504 (38%)
		Na_Ca_ex	120..262	CDD:279963	77/141 (55%)
		Na_Ca_ex	451..602	CDD:279963	76/156 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577429
Domainoid	1	1.000	187	1.000	Domainoid score	I3263
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1859
OMA	1	1.010	-	-		QHG50092
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	1	1.000	-	-		otm25347
orthoMCL	1	0.900	-	-		OOG6_103920
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810