DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and Slc24a5

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_778199.2	Gene:	Slc24a5 / 317750	MGIID:	2677271	Length:	501	Species:	Mus musculus

Alignment Length:	535	Identity:	182/535 - (34%)
Similarity:	279/535 - (52%)	Gaps:	91/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NCTQPAI---DDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSN 82
            |.||.|:   .:||...|::.:...|.:|::.:..||:.:|:::|||:||:|::|.|..:|.:|.
Mouse    42 NSTQCAVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIISDSLGLSQ 106

  Fly    83 DVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWP 147
            ||||||||||.:|||||....:|.|||:||||:.||:|||::|:|.:.|.||:.:.|...|..||
Mouse   107 DVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWP 171

  Fly   148 LTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFD--------KTFQKCAKGGV 204
            |.||...|.|:|..:..::.|.|:.|||...|:.:|.:|:.::.||        ||...|.
Mouse   172 LFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCSPCC---- 232

  Fly   205 KQARSRSRSSNCSIHTKNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISIT 269
             ...:|:........|....|.|.:|...|      ..:.:.|:.:|.      ||....::|:
Mouse   233 -PCLARAMEERIEQQTLLGWEDESQLFIRR------QSRTDSGIFQED------SGYSQLSLSL- 283

  Fly   270 TSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGYSLLSYP 334
                       |         ||                   |.|:         |:..|:.|.|
Mouse   284 -----------H---------GL-------------------SQVS---------EDPPSVFSMP 300

  Fly   335 KDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDT 399
              ::...:..|::..||..|..:..|||::......|.:||.|..:||.:.:|::.||:|:.|:|
Mouse   301 --EADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGET 363

  Fly   400 LKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVF-- 462
            |.|||:|||:|.||||||:|:.|:||:||::|.|.|.|.|.:|||.|| :||||:||.||..|
Mouse   364 LGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFD-MLCLGLPWFIKTAFTN 427

  Fly   463 --FPIQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASL 525
              .||:       :||.||.|..|:|..::..|:|....|.:|||:|:|..|||:||.....:.|
Mouse   428 ASAPIE-------VNSKGLTYITISLNISILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVL 485

  Fly   526 IELNVFFRVNLPTCG 540
            .|:.:.....:..||
Mouse   486 YEIGIIGNNRIRGCG 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	170/487 (35%)
		Na_Ca_ex	48..192	CDD:279963	64/143 (45%)
		Na_Ca_ex	370..525	CDD:279963	73/158 (46%)
Slc24a5	NP_778199.2	Na_Ca_ex	72..216	CDD:279963	64/143 (45%)
		TIGR00367	77..477	CDD:273039	167/475 (35%)
		Na_Ca_ex	334..485	CDD:279963	73/158 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880