DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and Slc24a5

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_038960915.1	Gene:	Slc24a5 / 311387	RGDID:	1310565	Length:	503	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	190/536 - (35%)
Similarity:	283/536 - (52%)	Gaps:	92/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NCTQ----PAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMS 81
            |.||    ||..:||...|::.:...|.:|::.:.:||:|:|:::|||:||:|::|.|..:|.:|
  Rat    43 NSTQCAVSPASSEFPEGFFTKQESTDGGIVIYFLITLYMFMAVSIVCDKYFLPSLEIISDSLGLS 107

  Fly    82 NDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWW 146
            .||||||||||.:|||||....:|.|||:||||:.||:|||::|:|.:.|.||:.:.|...|..|
  Rat   108 QDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCW 172

  Fly   147 PLTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFD--------KTFQKCAKGG 203
            ||.||...|.|:|..:..::.|.||.|||..:|:.:|.:|:.::.||        ||.:.|....
  Rat   173 PLFRDCAVYAVSVGAVFGIIFDNRVYWYEGALLLLIYGLYVLLLCFDTTISRYVTKTCRPCCPCL 237

  Fly   204 VKQARSRSRSSNCSIHTKNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISI 268
            .|....||..     .|....|.|.::...|      ..:.:.|:.:|.      ||....::|:
  Rat   238 AKAMEERSEQ-----QTLLGWENESQIYIRR------QSRTDSGIFQED------SGYSQLSLSL 285

  Fly   269 TTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGYSLLSY 333
                        |         ||                   |.|:         |:..|:.|.
  Rat   286 ------------H---------GL-------------------SQVS---------EDPPSVFSM 301

  Fly   334 PKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGD 398
            |  ::...:..|::..|:..|..:..|||::......|.:||.|...||.:.:||:.||:||.|:
  Rat   302 P--EADLRRIFWVLSLPVITLLALTTPDCRRKLWKNYFVITFFMSAFWISAFTYVLVWMVTITGE 364

  Fly   399 TLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVF- 462
            ||.|||:|||:|.||||||:|:.|:||:||::|.|.|.|.|.:|||.|| :||||:||.||..|
  Rat   365 TLGIPDTVMGLTLLAAGTSIPDTVASVLVARKGKGDMAISNIVGSNVFD-MLCLGLPWFIKTAFT 428

  Fly   463 ---FPIQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFAS 524
               .||:       :||.||.|..|:|..::|||:|....|.:|||:|:|..|||.||.....:.
  Rat   429 NASAPIE-------VNSKGLTYITISLNISIFLLFLAVHFNGWKLDRKLGVVCLVSYLGLATLSV 486

  Fly   525 LIELNVFFRVNLPTCG 540
            |.||.:.....:..||
  Rat   487 LYELGIIGNNRVRGCG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	176/487 (36%)
		Na_Ca_ex	48..192	CDD:279963	66/143 (46%)
		Na_Ca_ex	370..525	CDD:279963	77/158 (49%)
Slc24a5	XP_038960915.1	2A1904	<20..>241	CDD:273344	82/197 (42%)
Slc24a5	XP_038960915.1	2A1904	<293..493	CDD:273344	90/209 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920