DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zyd and SLC24A5

DIOPT Version :9

Sequence 1:	NP_001015261.3	Gene:	zyd / 3354992	FlyBaseID:	FBgn0265767	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_995322.1	Gene:	SLC24A5 / 283652	HGNCID:	20611	Length:	500	Species:	Homo sapiens

Alignment Length:	537	Identity:	177/537 - (32%)
Similarity:	279/537 - (51%)	Gaps:	96/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NCTQPAI---DDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSN 82
            |.||..|   .:||...|:..:|:.|.::::.:..:|:|:|:::||||||:|::|.|..:|.:|.
Human    42 NSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQ 106

  Fly    83 DVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWP 147
            ||||.|||||.:|||||....:|.|||:||||:.||:|||::|:|.:.|.||:.:.....|..||
Human   107 DVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWP 171

  Fly   148 LTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFD-----KTFQKCAKGGVKQA 207
            |.||..||.::.|.::.:::|.:|.|||..:|:.:|.:|:.|:.||     ...:||:......|
Human   172 LFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLA 236

  Fly   208 RSRSRSSNCSIHTKNSNEKEPELVENRICQNMANIQLNGGLNKEQ----AKATSTSG-----AGT 263
            ::..||           |::|               |.|..::.|    .::.:.||     :|.
Human   237 KAMERS-----------EQQP---------------LMGWEDEGQPFIRRQSRTDSGIFYEDSGY 275

  Fly   264 TAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGY 328
            :.:||:..                |...:...|.::..|...|
Human   276 SQLSISLH----------------GLSQVSEDPPSVFNMPEAD---------------------- 302

  Fly   329 SLLSYPKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMI 393
                       ..:..|::..||..|..:..|||:|......|.:||.|..:||.:.:|::.||:
Human   303 -----------LKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMV 356

  Fly   394 TIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLI 458
            ||.|:||:|||:|||:|.||||||:|:.::||:||::|.|.|.:.|.:|||.|| :||||:||.|
Human   357 TITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFD-MLCLGIPWFI 420

  Fly   459 KAVFFPIQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFA 523
            |..|.   .|.....:||.||.|..|:|..::..|:|....|.:|||:|:|..||:.||.....:
Human   421 KTAFI---NGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLS 482

  Fly   524 SLIELNVFFRVNLPTCG 540
            .|.||.:.....:..||
Human   483 VLYELGIIGNNKIRGCG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	ECM27	46..522	CDD:223604	163/489 (33%)
		Na_Ca_ex	48..192	CDD:279963	64/143 (45%)
		Na_Ca_ex	370..525	CDD:279963	70/154 (45%)
SLC24A5	NP_995322.1	Na_Ca_ex	<20..>224	CDD:332332	75/181 (41%)
SLC24A5	NP_995322.1	Na_Ca_ex	<290..490	CDD:332332	84/236 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880