Protein Alignment zyd and SLC24A4

DIOPT Version :10

• Sequence 1: NP_001015261.3
• Gene: zyd / 3354992
• FlyBaseID: FBgn0265767
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: XP_011534738.1
• Gene: SLC24A4 / 123041
• HGNCID: 10978
• Length: 669
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 220/573 - (38%)
• Similarity: 320/573 - (55%)
• Gaps: 84/573 - (14%)

  Fly    21 NCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVA 85
            |||.|||.:||.||||..:||.|||:||::.:||:|.|||:|||::|||::||||..|::|.|||
Human   123 NCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVA 187

  Fly    86 GATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTR 150
            |||||||.:|.||||.:|||.|||.||:||||||||||||||.:...||:.||..:.|.||.:.|
Human   188 GATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCR 252

  Fly   151 DSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKCAKGGVKQ--------A 207
            ||:.|.::|.:||..::||::.|:|.|:|:.||..|:.:|.::...|  |...|||        .
Human   253 DSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQ--AFFTVKQKSIANGNPV 315

  Fly   208 RSRSRSSN---------CSIHTKNSNEKEPELVENRICQNMANIQLNGGLNKEQAK--------- 254
            .|...:.|         .|:......:::|:..:|.:      :.::..::....|
Human   316 NSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPV------VMVDEIMSSSPPKFTFPEAGLR 374

  Fly   255 --ATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAES----H 313
              .|:..|..|.....:...:.......:||.|              |...||.:...|:    :
Human   375 IMITNKFGPRTRLRMASRIIINERQRLINSANG--------------VSSKPLQNGRHENIENGN 425

  Fly   314 VAVAAADEGRKEEG-------------------YSLLSYPKDKSCFAQFTWLIIWPIHLLFRIAI 359
            |.|...::.::.:.                   .|..|.|:.:.  .:..|:..||:..|..:.|
Human   426 VPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARG--DKVKWVFTWPLIFLLCVTI 488

  Fly   360 PDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSS 424
            |:|.|.:..|.|.:|||...:||...||::.|::||||.||.|||.:|||||||||||||:.::|
Human   489 PNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 553

  Fly   425 VIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPGQNY---VAINSAGLEYSAITL 486
            :|||::|.|.|.:.|:||||.||||:.|||||.::.:..      ||   |.|||.||.||.:.|
Human   554 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVV------NYGSTVKINSRGLVYSVVLL 612

  Fly   487 LSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIELNVFFRVNLPTC 539
            |.::.|..|....||::||:|:|...||:|.:|:.|:.:||.|||..||||.|
Human   613 LGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMC 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zyd	NP_001015261.3	2A1904	<29..527	CDD:273344	204/551 (37%)
SLC24A4	XP_011534738.1	2A1904	<75..653	CDD:273344	210/559 (38%)