DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17167 and SLC24A1

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_004718.1	Gene:	SLC24A1 / 9187	HGNCID:	10975	Length:	1099	Species:	Homo sapiens

Alignment Length:	679	Identity:	161/679 - (23%)
Similarity:	265/679 - (39%)	Gaps:	235/679 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLDILPRAQCPGEDEGSPMDEFADLFTVDQLRQGWVVLHVFAAVYFFILLAIICNDYFLPTVECI 112
            |.|:.|:.:.|           .|||:|::.||||||||||..:|.|:.|||:|::||:|.:..|
Human   431 LPDLHPKGEYP-----------PDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVI 484

  Fly   113 CEDLHLSKDVAAATFMATATSMPEFFTNTISTLILESDMGLGTIIGSLMFNTLGVAGLAALAIDK 177
            .:.|.:|:|||.|||||...|.||.||:.|...|..|::|:|||:||.:||.|.|.|..:|...:
Human   485 TDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSRE 549

  Fly   178 PVQLDWWPIARDCFIYVFNTIILLVLAWSGSISFTESCIMMGFLILYYLITFNNNKFMPAIRVFI 242
            .:.|.|||:.||...|:.:.|:|::......|::.||.::: ....:|:.|...||.   |.|::
Human   550 ILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLL-LAYAFYVFTMKWNKH---IEVWV 610

  Fly   243 EDRM--------------------------------------------------NCCFSTRYDL- 256
            ::::                                                  :...||.|.|
Human   611 KEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLM 675

  Fly   257 -------------TEPPENS----------AKAQ-LPLKKDPLSGDGLFVLNLP----------- 286
                         .|..|.|          |||: .|.:::|.....:.|...|
Human   676 LHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKEN 740

  Fly   287 ----------ENTSSMSSTANLTRNKHLNDEDDVADVVP-------------------------- 315
                      |:|..|......|..:...:|....:..|
Human   741 PGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGD 805

  Fly   316 ------GSIYAYPRDASG----------------------------------------------- 327
                  |.|:|...:..|
Human   806 NEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQE 870

  Fly   328 ------------------------------W-----MQFWWIFVFPIKVTLSLLIP--HPMKYRR 355
                                          |     .|..::|:.||...|.|.:|  ...:.|:
Human   871 EEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRK 935

  Fly   356 LYPLSFIMCILCIGGNAYLIVWMLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENG 420
            .:..:|:..|:.|...:||:||.....|..|.:...:||||.||||:::|:.::|:|..|.|...
Human   936 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD 1000

  Fly   421 IGVSNSLGANSLAILLSLGVPWFIKNCIHYGTG-EPQQVGTQGIEYNILILIISTMALFIILSFS 484
            :.||:|:|:|...|.:.|.|||.:.:.|:   | :|..|.:.|:...|::|.:  |.||:|.|.:
Human  1001 MAVSSSVGSNIFDITVGLPVPWLLFSLIN---GLQPVPVSSNGLFCAIVLLFL--MLLFVISSIA 1060

  Fly   485 G--YRLTKRVGVALFTVYGVFIVLQILIE 511
            .  :|:.|.:|..:|.:|.||:::.:::|
Human  1061 SCKWRMNKILGFTMFLLYFVFLIISVMLE 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	144/632 (23%)
		Na_Ca_ex	86..229	CDD:279963	56/142 (39%)
		Na_Ca_ex	356..509	CDD:279963	51/155 (33%)
SLC24A1	NP_004718.1	2A1904	1..1099	CDD:273344	161/679 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..304
		Alpha-1	494..534		21/39 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..901		20/210 (10%)
		Alpha-2	979..1010		12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820