DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17167 and Slc24a3

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_445957.2	Gene:	Slc24a3 / 85267	RGDID:	69256	Length:	642	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	171/595 - (28%)
Similarity:	277/595 - (46%)	Gaps:	134/595 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TVTQAKAATSNASSFLEVSLRYFDEQLLLDILPRAQCPGEDEGSPMDEFADLFTVDQLRQGWVVL 85
            |:|...|...::.:..|.:|..|         ||                |:|:.:..|||.|||
  Rat    72 TLTSEDAGLRSSKNCTEPALHEF---------PR----------------DIFSNEDRRQGAVVL 111

  Fly    86 HVFAAVYFFILLAIICNDYFLPTVECICEDLHLSKDVAAATFMATATSMPEFFTNTISTLILESD 150
            ||..|:|.|..|||:|:|:|:|::|.|||.||||:|||.|||||..:|.||.||:.|...|.:.|
  Rat   112 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGD 176

  Fly   151 MGLGTIIGSLMFNTLGVAGLAALAIDKPVQLDWWPIARDCFIYVFNTIILLVLAWSGSISFTESC 215
            :|:|||:||.:||.|.:.|:..|...:.|.|..|.:.||...|..:.:.|:|..:...:|:.||.
  Rat   177 VGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESL 241

  Fly   216 IMMGFLILYYLITFNNNKFMPAI--------------------RVFIEDRMNC------------ 248
            :    |:|.|||.....|:...|                    ...|:|..||
  Rat   242 V----LVLMYLIYIIIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANF 302

  Fly   249 --------------------CFS---TRYDLTE--PPE---NSAKAQLPLKKDPL-------SGD 278
                                .||   .|..:|.  ||:   :.|...|..::..|       :|:
  Rat   303 HRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGE 367

  Fly   279 GLFVLNLP-----ENTSSMSST----ANLTR--------------------NKHLNDEDDVADVV 314
            ....:.:|     ||.:..||.    .|.||                    |::..:||:..|..
  Rat   368 SEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEG 432

  Fly   315 PGSIYAYPRDASGWMQ-FWWIFVFPIKVTLSLLIPHPMK--YRRLYPLSFIMCILCIGGNAYLIV 376
            |.:.:..|   ||.:: ..|.|.:|:...|...:|:..|  :.:.:.::|....|.|...:|::|
  Rat   433 PYTPFDPP---SGKLETVKWAFTWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMV 494

  Fly   377 WMLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENGIGVSNSLGANSLAILLSLGVP 441
            ||:|..|..:.:|.::||:||||||:::|:.::|||..|.|...:.||||:|:|...||:.||:|
  Rat   495 WMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLP 559

  Fly   442 WFIKN-CIHYGTGEPQQVGTQGIEYNILILIISTMALFIILSFSGYRLTKRVGVALFTVYGVFIV 505
            |.::. .:.||:  ..::.::|:.|::.:|:.|.......:..:.::|.|::|.....:||||:.
  Rat   560 WALQTLAVDYGS--YIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLC 622

  Fly   506 LQILIEMNVF 515
            ..|:.|.|||
  Rat   623 FSIMTEFNVF 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	149/517 (29%)
		Na_Ca_ex	86..229	CDD:279963	63/142 (44%)
		Na_Ca_ex	356..509	CDD:279963	49/153 (32%)
Slc24a3	NP_445957.2	TIGR00367	111..604	CDD:273039	144/501 (29%)
		Na_Ca_ex	112..254	CDD:279963	63/145 (43%)
		Na_Ca_ex	474..626	CDD:279963	49/153 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950