DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17167 and SLC8A2

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_055878.1	Gene:	SLC8A2 / 6543	HGNCID:	11069	Length:	921	Species:	Homo sapiens

Alignment Length:	220	Identity:	46/220 - (20%)
Similarity:	86/220 - (39%)	Gaps:	65/220 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 FWWIFVFPIKVTLSLLIPHPMKYRRLYPLSFIMCILCIG----GNAYLIVWMLTA--------FG 383
            ||.:        |...:| |.:|             |.|    |.:.|::.:|||        ||
Human   732 FWKV--------LFACVP-PTEY-------------CHGWACFGVSILVIGLLTALIGDLASHFG 774

  Fly   384 VAIHVPTIVMGLTFLAAGSTMPEAVSSLI-SLRNGENGIGVSNSLGANSLAILLSLGVPWFIKNC 447
            ..:.:...|..:.|:|.|:::|:..:|.: :|::......:.|..|:|::.:.|.|||.|.:...
Human   775 CTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAV 839

  Fly   448 IHYGTGEPQQVGTQGIEYNILILIISTMALFIILSFSG-----YRLTKRVG-------------- 493
            .....|.|.:|.|..:.:::        .||.:.:|.|     ||....:|
Human   840 YWAVQGRPFEVRTGTLAFSV--------TLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATT 896

  Fly   494 ---VALFTVYGVFIVLQILIEMNVF 515
               :.|:.:|.:|..|:....:..|
Human   897 ALFLGLWLLYILFASLEAYCHIRGF 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	43/206 (21%)
		Na_Ca_ex	86..229	CDD:279963
		Na_Ca_ex	356..509	CDD:279963	39/187 (21%)
SLC8A2	NP_055878.1	caca	1..921	CDD:273296	45/218 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..42
		Alpha-1	135..175
		Putative calmodulin-binding region. /evidence=ECO:0000250\|UniProtKB:P23685	248..267
		Alpha-2	790..826		8/35 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4242
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860