Protein Alignment CG17167 and SLC24A3

DIOPT Version :9

• Sequence 1: NP_001015257.2
• Gene: CG17167 / 3354991
• FlyBaseID: FBgn0039941
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_065740.2
• Gene: SLC24A3 / 57419
• HGNCID: 10977
• Length: 644
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 170/597 - (28%)
• Similarity: 271/597 - (45%)
• Gaps: 138/597 - (23%)

  Fly    21 TVTQAKAATSNASSFLEVSLRYFDEQLLLDILPRAQCPGEDEGSPMDEFADLFTVDQLRQGWVVL 85
            |:|...|...|:.:..|.:|..|..                         |:||.:..|||.|||
Human    73 TLTSEDAGLRNSKNCTEPALHEFPN-------------------------DIFTNEDRRQGAVVL 112

  Fly    86 HVFAAVYFFILLAIICNDYFLPTVECICEDLHLSKDVAAATFMATATSMPEFFTNTISTLILESD 150
            ||..|:|.|..|||:|:|:|:|::|.|||.||||:|||.|||||..:|.||.||:.|...|.:.|
Human   113 HVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGD 177

  Fly   151 MGLGTIIGSLMFNTLGVAGLAALAIDKPVQLDWWPIARDCFIYVFNTIILLVLAWSGSISFTESC 215
            :|:|||:||.:||.|.:.|:..|...:.|.|..|.:.||...|..:.|.|:|..:...:|:.||.
Human   178 VGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESL 242

  Fly   216 IMMGFLILYYLITFNNNKFMPAI--------------------RVFIEDRMNC------------ 248
            :    |:|.|||.....|:...|                    ...|:|..||
Human   243 V----LVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANF 303

  Fly   249 --------------------CFS---TRYDLTE--PP---------------------------E 261
                                .||   .|..:|.  ||                           |
Human   304 HRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGE 368

  Fly   262 NSAKAQLPLKKDPLSGDGLFV-----LNLPENTSSMSSTANLTRNKHLN---------DEDDVAD 312
            :....::|:|....:|.|...     :|.......::...|.|.|::.:         ||||  |
Human   369 SEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDD--D 431

  Fly   313 VVPGSIYAYPRDASGWMQ-FWWIFVFPIKVTLSLLIPHPMK--YRRLYPLSFIMCILCIGGNAYL 374
            ..|.:.:..|   ||.:: ..|.|.:|:...|...:|:..|  :.:.:.::|....|.|...:|:
Human   432 EGPYTPFDTP---SGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYM 493

  Fly   375 IVWMLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENGIGVSNSLGANSLAILLSLG 439
            :|||:|..|..:.:|.::||:||||||:::|:.::|||..|.|...:.||||:|:|...||:.||
Human   494 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLG 558

  Fly   440 VPWFIKN-CIHYGTGEPQQVGTQGIEYNILILIISTMALFIILSFSGYRLTKRVGVALFTVYGVF 503
            :||.::. .:.||:  ..::.::|:.|::.:|:.|.......:..:.::|.|::|.....:||||
Human   559 LPWALQTLAVDYGS--YIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVF 621

  Fly   504 IVLQILIEMNVF 515
            :...|:.|.|||
Human   622 LCFSIMTEFNVF 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	148/519 (29%)
		Na_Ca_ex	86..229	CDD:279963	64/142 (45%)
		Na_Ca_ex	356..509	CDD:279963	49/153 (32%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	143/503 (28%)
		Na_Ca_ex	113..255	CDD:279963	64/145 (44%)
		Alpha-1	149..189		21/39 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..442		10/41 (24%)
		Na_Ca_ex	475..627	CDD:279963	49/153 (32%)
		Alpha-2	518..549		14/30 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850