DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17167 and slc24a5

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001025451.1	Gene:	slc24a5 / 570312	ZFINID:	ZDB-GENE-031210-1	Length:	513	Species:	Danio rerio

Alignment Length:	462	Identity:	129/462 - (27%)
Similarity:	244/462 - (52%)	Gaps:	39/462 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EFAD-LFTVDQLRQGWVVLHVFAAVYFFILLAIICNDYFLPTVECICEDLHLSKDVAAATFMATA 131
            ||.: .|||.:.:.|.::::.....|..:.::|:|::||||::|.|.|.|.||:|||.|||||..
Zfish    65 EFPEGFFTVQERKDGGILIYFMIIFYMLLSVSIVCDEYFLPSLEVISERLGLSQDVAGATFMAAG 129

  Fly   132 TSMPEFFTNTISTLILESDMGLGTIIGSLMFNTLGVAGLAALAIDKPVQLDWWPIARDCFIYVFN 196
            :|.||..|..:...:.:.|:|:.||:||.::|.|.:.....|......:|..||:.|||..|..:
Zfish   130 SSAPELVTAFLGVFVTKGDIGVSTIMGSAVYNLLCICAACGLLSSAVGRLSCWPLFRDCVAYAIS 194

  Fly   197 TIILLVLAWSGSISFTE-SCIMMGFLILYYLITFNNNKFMPAIRV--FIEDRMN-CCFSTRYDLT 257
            ...::.:.....:.:.: :|:::.:.:...::.|:       :|:  ::..|.: ||:..:
Zfish   195 VAAVIAIISDNRVYWYDGACLLLVYGVYVAVLCFD-------LRISEYVMQRFSPCCWCLK---- 248

  Fly   258 EPPENSAKAQLPLK--KDPLSGDGLFVLNLPENTSSM----SSTANLTRNKH-LNDEDDVADVVP 315
             |.:..:..|.||.  .|..|   |.|.....|.|.:    |..::|:.:.| ||:..|...
Zfish   249 -PRDRDSGEQQPLVGWSDDSS---LRVQRRSRNDSGIFQDDSGYSHLSLSLHGLNEISDEHK--- 306

  Fly   316 GSIYAYP-RDASGWMQFWWIFVFPIKVTLSLLIPHPMK--YRRLYPLSFIMCILCIGGNAYLIVW 377
             |:::.| .|..   :..|:...|:...|.:.:|...:  ::..|.|:|:|..:.|....|::||
Zfish   307 -SVFSMPDHDLK---RILWVLSLPVSTLLFVSVPDCRRPFWKNFYMLTFLMSAVWISAFTYVLVW 367

  Fly   378 MLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENGIGVSNSLGANSLAILLSLGVPW 442
            |:|..|..:.:|..|||:|.||||:::|:.|:|::..|.|::.:.:||.:|:| :..:|.||:||
Zfish   368 MVTIVGETLGIPDTVMGMTLLAAGTSIPDTVASVMVAREGKSDMAMSNIVGSN-VFDMLCLGLPW 431

  Fly   443 FIKNCIHYGTGEPQQVGTQGIEYNILILIISTMALFIILSFSGYRLTKRVGVALFTVYGVFIVLQ 507
            ||:. :....|.|.:|.:.|:.:....|::|.:.||:.:..:|::|..::|:.....|.:|..|.
Zfish   432 FIQT-VFVDVGSPVEVNSSGLVFMSCTLLLSIIFLFLAVHINGWKLNWKLGLVCLACYILFATLS 495

  Fly   508 ILIEMNV 514
            ||.|:.:
Zfish   496 ILYELGI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	118/431 (27%)
		Na_Ca_ex	86..229	CDD:279963	42/143 (29%)
		Na_Ca_ex	356..509	CDD:279963	50/152 (33%)
slc24a5	NP_001025451.1	ECM27	81..497	CDD:223604	120/439 (27%)
		Na_Ca_ex	84..228	CDD:279963	42/143 (29%)
		Na_Ca_ex	346..497	CDD:279963	50/152 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63129
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930