DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17167 and Slc24a5

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_778199.2	Gene:	Slc24a5 / 317750	MGIID:	2677271	Length:	501	Species:	Mus musculus

Alignment Length:	481	Identity:	140/481 - (29%)
Similarity:	240/481 - (49%)	Gaps:	44/481 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LPRA-----QCPGEDEGSPMDEFAD-LFTVDQLRQGWVVLHVFAAVYFFILLAIICNDYFLPTVE 110
            ||||     ||    ..||..||.: .||..:...|.:|::....:|..:.::|:|:.||||::|
Mouse    36 LPRATGNSTQC----AVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLE 96

  Fly   111 CICEDLHLSKDVAAATFMATATSMPEFFTNTISTLILESDMGLGTIIGSLMFNTLGVAGLAALAI 175
            .|.:.|.||:|||.|||||..:|.||..|..:...|.:.|:|:.||:||.::|.||:.....|..
Mouse    97 IISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLS 161

  Fly   176 DKPVQLDWWPIARDCFIYVFNTIILLVLAWSGSISFTESCIMMGFLILY----YLITFNNNKFMP 236
            :....|..||:.|||.:|..:...:..:.:...|.:.|..   |.|::|    .|:.|:..
Mouse   162 NMVSTLSCWPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGA---GLLLIYGLYVLLLCFDTT---- 219

  Fly   237 AIRVFIEDRMNCCFSTRYDLTEPPENSA------KAQLPLKKDPLSGDGLFVLNLPENTSSMSST 295
            ..|..::....||......:.|..|...      ::||.:::...:..|:|     :..|..|..
Mouse   220 ISRHVMKTCSPCCPCLARAMEERIEQQTLLGWEDESQLFIRRQSRTDSGIF-----QEDSGYSQL 279

  Fly   296 ANLTRNKHLNDEDDVADVVPGSIYAYPRDASGWMQFWWIFVFPIKVTLSLLIPHPMK--YRRLYP 358
            :..........||      |.|:::.|.  :...:.:|:...||...|:|..|...:  ::..:.
Mouse   280 SLSLHGLSQVSED------PPSVFSMPE--ADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFV 336

  Fly   359 LSFIMCILCIGGNAYLIVWMLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENGIGV 423
            ::|.|..|.|....|::|||:|..|..:.:|..|||||.||||:::|:.|:|::..|.|:..:.:
Mouse   337 ITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAI 401

  Fly   424 SNSLGANSLAILLSLGVPWFIKNCIHYGTGEPQQVGTQGIEYNILILIISTMALFIILSFSGYRL 488
            ||.:|:| :..:|.||:|||||... .....|.:|.::|:.|..:.|.||.:.||:.:.|:|::|
Mouse   402 SNIVGSN-VFDMLCLGLPWFIKTAF-TNASAPIEVNSKGLTYITISLNISILFLFLAVHFNGWKL 464

  Fly   489 TKRVGVALFTVYGVFIVLQILIEMNV 514
            .:::||....:|.....|.:|.|:.:
Mouse   465 DRKLGVVCLVLYLGLATLSVLYEIGI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	123/429 (29%)
		Na_Ca_ex	86..229	CDD:279963	48/146 (33%)
		Na_Ca_ex	356..509	CDD:279963	53/152 (35%)
Slc24a5	NP_778199.2	Na_Ca_ex	72..216	CDD:279963	48/146 (33%)
		TIGR00367	77..477	CDD:273039	122/421 (29%)
		Na_Ca_ex	334..485	CDD:279963	53/152 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63129
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.890