DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17167 and Slc24a4

DIOPT Version :9

Sequence 1:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_742164.2	Gene:	Slc24a4 / 238384	MGIID:	2447362	Length:	622	Species:	Mus musculus

Alignment Length:	568	Identity:	163/568 - (28%)
Similarity:	281/568 - (49%)	Gaps:	106/568 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EQLLLDILPRAQCPGEDEGSPM---------DEF-ADLFTVDQLRQGWVVLHVFAAVYFFILLAI 99
            :.:|||.....:......|:|:         .|| .|||:..:.:.|.|:||:..|:|.|..|||
Mouse    52 KHVLLDTWRNRKLMAPINGTPLAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAI 116

  Fly   100 ICNDYFLPTVECICEDLHLSKDVAAATFMATATSMPEFFTNTISTLILESDMGLGTIIGSLMFNT 164
            :|:|:|:|::|.|||.||||:|||.|||||..:|.||.|.:.|...|...|:|:|||:||.:||.
Mouse   117 VCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 181

  Fly   165 LGVAGLAALAIDKPVQLDWWPIARDCFIYVFNTIILLVLAWSGSISFTESCIMMGFLILYYLITF 229
            |.:.|:..|...:.|:|.||.:.||...|..:.|:|:...:...|.:.|..:::...:.|.||..
Mouse   182 LCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMK 246

  Fly   230 NNNKFMPAIRVF-----------------IEDRMNCCFSTRYDLTEPPENSAKAQLPLKKDPL-- 275
            .|.|    ::.|                 :||..:....:..|.:.|.....|.:.|..|.|:
Mouse   247 YNMK----MQTFFTTKQKSIANGNPVSNELEDGNDLYDGSYDDPSVPLLGQVKEKPPYGKTPVVM 307

  Fly   276 ----------------SGDGLFVLNL--PENTSSMSS------------TANLTRNKHL------ 304
                            :|..:.:.|.  |.....|:|            :||...:|.|
Mouse   308 VDEILSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVNSKPLQNGRHE 372

  Fly   305 ----------NDED------------------DVADVVPGSIYAYPRDASGWMQFWWIFVFPIKV 341
                      |.||                  :..:.|..|.::.| :|.| .:..|:|.:|:..
Mouse   373 NMENGNVPVENPEDPQQGQEQQPPPQPPPPEPESVETVFLSPFSMP-EAKG-DKAKWVFTWPLIF 435

  Fly   342 TLSLLIPHPMK--YRRLYPLSFIMCILCIGGNAYLIVWMLTAFGVAIHVPTIVMGLTFLAAGSTM 404
            .|.:.||:..|  :.:.:.::||...|.|...:||:||::|..|..:.:|.::||:||||||:::
Mouse   436 LLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSV 500

  Fly   405 PEAVSSLISLRNGENGIGVSNSLGANSLAILLSLGVPWFIKN-CIHYGTGEPQQVGTQGIEYNIL 468
            |:.::|||..|.|...:.|||::|:|...||:.||:||.::. .|:||:  ..::.::|:.|::
Mouse   501 PDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGS--TVKINSRGLVYSV- 562

  Fly   469 ILIISTMALFII-LSFSGYRLTKRVGVALFTVYGVFIVLQILIEMNVF 515
            :|::.::||.:: :..:.:||.:::|:.:..:|.||:...|:||.|||
Mouse   563 VLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFSIMIEFNVF 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	143/504 (28%)
		Na_Ca_ex	86..229	CDD:279963	59/142 (42%)
		Na_Ca_ex	356..509	CDD:279963	50/154 (32%)
Slc24a4	NP_742164.2	Na_Ca_ex	<80..606	CDD:332332	153/534 (29%)
		Alpha-1	139..179		20/39 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..408		7/49 (14%)
		Alpha-2	495..526		13/30 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850