DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12061 and Slc24a3

DIOPT Version :9

Sequence 1:	NP_001104467.2	Gene:	CG12061 / 3354990	FlyBaseID:	FBgn0040031	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001343426.1	Gene:	Slc24a3 / 94249	MGIID:	2137513	Length:	645	Species:	Mus musculus

Alignment Length:	551	Identity:	173/551 - (31%)
Similarity:	261/551 - (47%)	Gaps:	158/551 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ARNCTLPAIVEFP-----NLMRQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRMT 93
            ::|||.||:.|||     |..|::.  |:|:..|.:||:|..|||||||:.||::|::|..|.::
Mouse    83 SKNCTEPALHEFPRDIFSNEDRRQG--AVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLS 145

  Fly    94 YDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFT-QPTKLDWW 157
            .|||||||:||.:||||||.:.:|.|:|.||:|:||||||:|||||.|.||||:|. |...|..|
Mouse   146 EDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSW 210

  Fly   158 PVTRDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLS--------FDRRIQ---NLV 211
            .:.||:.:|.:::.:|...::|..|.|:|:..|:|:|:.|::.:.        |:||.:   |:|
Mouse   211 CLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMV 275

  Fly   212 R--------------------------HEHAESELLDE------------------------DPM 226
            .                          |..|...::||                        .|.
Mouse   276 NGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPK 340

  Fly   227 TR------------------------EEE--------------------PLKGF----RDHVCAK 243
            ||                        |.|                    |.:|.    ||.:.|:
Mouse   341 TRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAE 405

  Fly   244 ------------------------------PKTEYN----FYQWTWWAIKYPAELMLACTVPSA- 273
                                          |.|.::    ..:...||..:|...:|..|||:.
Mouse   406 TDNETENENEDNENNENDEEEEEDEDDDEGPYTPFDPPSGKLETVKWAFTWPLSFVLYFTVPNCN 470

  Fly   274 ----RSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVS 334
                ...|.::..|:.|||:..||::.|.:||:||.|.|||.|||:|.||||||||:..:|.||:
Mouse   471 KPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 535

  Fly   335 KKGYGSMAICNAIGSNTFDILVCLGLPWLLKILI--YQQKIDIDSTALTITTAMLVVTAAVLYLG 397
            ::|.|.||:.|:||||.||||:.|||||.|:.|.  |...|.::|..|..:..:|:.:..|...|
Mouse   536 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFG 600

  Fly   398 LLARRFVMGKTVGYLSIIFYALFLIIACTLE 428
            :...::.:.|.:|...:..|.:||..:...|
Mouse   601 VHLNKWQLDKKLGCGCLFLYGVFLCFSIMTE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	159/511 (31%)
		Na_Ca_ex	62..199	CDD:279963	69/137 (50%)
		Na_Ca_ex	276..424	CDD:279963	63/149 (42%)
Slc24a3	NP_001343426.1	Na_Ca_ex	<89..631	CDD:332332	169/543 (31%)
		Alpha-1	148..188		26/39 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..398		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..442		3/37 (8%)
		Alpha-2	520..551		17/30 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840