Protein Alignment CG12061 and SLC24A3

DIOPT Version :9

• Sequence 1: NP_001104467.2
• Gene: CG12061 / 3354990
• FlyBaseID: FBgn0040031
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_065740.2
• Gene: SLC24A3 / 57419
• HGNCID: 10977
• Length: 644
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 173/549 - (31%)
• Similarity: 264/549 - (48%)
• Gaps: 155/549 - (28%)

  Fly    33 DARNCTLPAIVEFPNLM-----RQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRM 92
            :::|||.||:.||||.:     |::.  |:|:..|.::|:|..|||||||:.||::|::|..|.:
Human    83 NSKNCTEPALHEFPNDIFTNEDRRQG--AVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHL 145

  Fly    93 TYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFT-QPTKLDW 156
            :.|||||||:||.:||||||.:.:|.|:|.||:|:||||||:|||||.|.||||:|. |...|..
Human   146 SEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSS 210

  Fly   157 WPVTRDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLS--------FDRRIQ---NL 210
            |.:.||:.:|.:::.:|...::|..|.|:|:..|:|:|:.|::.:.        |:||.:   |:
Human   211 WCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNM 275

  Fly   211 VR--------------------------HEHAESELLDE------------------------DP 225
            |.                          |..|...::||                        .|
Human   276 VNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPP 340

  Fly   226 MTR------------------------EEE--------------------PLKGF----RDHVCA 242
            .||                        |.|                    |.:|.    ||.|.|
Human   341 KTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVA 405

  Fly   243 K---------------------------PKTEYNF----YQWTWWAIKYPAELMLACTVPSA--- 273
            :                           |.|.::.    .:...||..:|...:|..|||:.
Human   406 EAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKP 470

  Fly   274 --RSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKK 336
              ...|.::..|:.|||:..||::.|.:||:||.|.|||.|||:|.||||||||:..:|.||:::
Human   471 RWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 535

  Fly   337 GYGSMAICNAIGSNTFDILVCLGLPWLLKILI--YQQKIDIDSTALTITTAMLVVTAAVLYLGLL 399
            |.|.||:.|:||||.||||:.|||||.|:.|.  |...|.::|..|..:..:|:.:..|...|:.
Human   536 GMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH 600

  Fly   400 ARRFVMGKTVGYLSIIFYALFLIIACTLE 428
            ..::.:.|.:|...::.|.:||..:...|
Human   601 LNKWQLDKKLGCGCLLLYGVFLCFSIMTE 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	159/508 (31%)
		Na_Ca_ex	62..199	CDD:279963	68/137 (50%)
		Na_Ca_ex	276..424	CDD:279963	63/149 (42%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	155/492 (32%)
		Na_Ca_ex	113..255	CDD:279963	68/141 (48%)
		Alpha-1	149..189		26/39 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..442		3/36 (8%)
		Na_Ca_ex	475..627	CDD:279963	63/151 (42%)
		Alpha-2	518..549		17/30 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850