DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12061 and slc24a4a

DIOPT Version :9

Sequence 1:	NP_001104467.2	Gene:	CG12061 / 3354990	FlyBaseID:	FBgn0040031	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_005158898.1	Gene:	slc24a4a / 550467	ZFINID:	ZDB-GENE-050417-291	Length:	621	Species:	Danio rerio

Alignment Length:	513	Identity:	167/513 - (32%)
Similarity:	264/513 - (51%)	Gaps:	119/513 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RNCTLPAIVEFPNLM---RQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRMTYDV 96
            :|||.|||.|||..:   :|:|..|:::....::|:|:.||||||||.|.::|::|..|.::.||
Zfish    92 KNCTAPAIHEFPEDLFTNQQRSQGAVLLHIFAALYMFLALAIVCDDYFVTSLEKICEKLHLSEDV 156

  Fly    97 AGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFT-QPTKLDWWPVT 160
            |||||:||.:||||||.:.:|.|:|:||:|:||||||:|||||.|.||||||. |...|..:.|.
Zfish   157 AGATFMAAGSSAPELFASIIGVFITHGDVGVGTIVGSAVFNILCIIGVCGIFAGQVVFLTKYAVF 221

  Fly   161 RDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLSFDRRIQNL--------VRHEHAE 217
            ||:::|:|::.:|...::|..::|:|:..|:::|:.|:|.:.|:..:|||        |.:.:|.
Zfish   222 RDSSYYIISVIALIVFIYDDEILWWESLVLIVMYLGYIIVMKFNTSLQNLFNGKEDKRVTNGNAV 286

  Fly   218 SELLD----------EDPMTREEEPLK-----------------------------GFR------ 237
            |..::          :||......|:|                             |.|
Zfish   287 SSEMEPGNDCFEQFWDDPSWPLLAPVKPNKIYTRGSVVMVDEMMNSSPPHYRFPEAGLRVMITNH 351

  Fly   238 ------------------------------------------------DHVCAKPKTEYNFYQWT 254
                                                            |.:..:.:.|.:.::..
Zfish   352 FGPKTRLRMASRLIINEQQRLVKSANGVDSVLVSDQKADTMENGNVAEDKLSEEQENEISPFRLP 416

  Fly   255 WWA-------IKYPAELMLACTVPSA-----RSIFFLSMISAILWISLISYLLTWFLTILGYNLN 307
            ..|       |.:|..|:|..|:|:.     ...|.||...:.:||:..||:|.|.:||:||.|.
Zfish   417 EGAMDTVKFFISWPISLLLYFTIPNCAKKRWECCFMLSFFLSTVWIAAFSYILVWMVTIVGYTLG 481

  Fly   308 IPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLKILI--YQ 370
            |||.|||:|.||||||||:..:|.||:::|.|.||:.|.||||.|||||.||:||.::.:.  |.
Zfish   482 IPDVIMGITFLAAGTSVPDCIASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGIQTMAVNYG 546

  Fly   371 QKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYLSIIFYALFLIIACTLE 428
            ..:.|:|..|..:..:|:.:.|:..||:...|:.:...:|...::.||:||..:..:|
Zfish   547 SVVKINSRGLVYSVVLLLGSVALTVLGIHVNRWRLDLRLGIYVLVLYAIFLTFSIMIE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	153/476 (32%)
		Na_Ca_ex	62..199	CDD:279963	67/137 (49%)
		Na_Ca_ex	276..424	CDD:279963	64/149 (43%)
slc24a4a	XP_005158898.1	TIGR00367	119..596	CDD:273039	152/476 (32%)
		Na_Ca_ex	120..262	CDD:279963	68/141 (48%)
		Na_Ca_ex	451..602	CDD:279963	64/150 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850