DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12061 and CG17167

DIOPT Version :9

Sequence 1:	NP_001104467.2	Gene:	CG12061 / 3354990	FlyBaseID:	FBgn0040031	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001015257.2	Gene:	CG17167 / 3354991	FlyBaseID:	FBgn0039941	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	132/464 - (28%)
Similarity:	221/464 - (47%)	Gaps:	97/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EFPNL-----MRQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRMTYDVAGATFLA 103
            ||.:|     :|| .|  :|:....::|.|::|||:|:||.:|.:|.:|..|.::.|||.|||:|
  Fly    68 EFADLFTVDQLRQ-GW--VVLHVFAAVYFFILLAIICNDYFLPTVECICEDLHLSKDVAAATFMA 129

  Fly   104 ASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGI-FTQPTKLDWWPVTRDTAWYL 167
            .:||.||.|.|.:.|.:...|:|||||:||.:||.|.:||:..: ..:|.:|||||:.||...|:
  Fly   130 TATSMPEFFTNTISTLILESDMGLGTIIGSLMFNTLGVAGLAALAIDKPVQLDWWPIARDCFIYV 194

  Fly   168 IAIASLTYVLWDSLVMWYEA---FALLLLYISYVIQLS-------------------FDRRIQ-- 208
            .....|..:.|...:.:.|:   ...|:||  |:|..:                   |..|..
  Fly   195 FNTIILLVLAWSGSISFTESCIMMGFLILY--YLITFNNNKFMPAIRVFIEDRMNCCFSTRYDLT 257

  Fly   209 ---------------------------------------NLVRHEHAESELLDEDPMTREEEPLK 234
                                                   ||.|::|    |.|||.:.   :.:.
  Fly   258 EPPENSAKAQLPLKKDPLSGDGLFVLNLPENTSSMSSTANLTRNKH----LNDEDDVA---DVVP 315

  Fly   235 GFRDHVCAKPKTEYNFYQWTWWAIKYPAELMLACTVP---SARSIFFLSMISAILWISLISYLLT 296
            |   .:.|.|:....:.|: ||...:|.::.|:..:|   ..|.::.||.|..||.|...:||:.
  Fly   316 G---SIYAYPRDASGWMQF-WWIFVFPIKVTLSLLIPHPMKYRRLYPLSFIMCILCIGGNAYLIV 376

  Fly   297 WFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLP 361
            |.||..|..:::|..:||||.||||:::||..||.|..:.|...:.:.|::|:|:..||:.||:|
  Fly   377 WMLTAFGVAIHVPTIVMGLTFLAAGSTMPEAVSSLISLRNGENGIGVSNSLGANSLAILLSLGVP 441

  Fly   362 WLLKILIY------QQKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYLSIIFYALF 420
            |.:|..|:      ||   :.:..:.....:|:::...|::.|....:.:.|.||......|.:|
  Fly   442 WFIKNCIHYGTGEPQQ---VGTQGIEYNILILIISTMALFIILSFSGYRLTKRVGVALFTVYGVF 503

  Fly   421 LIIACTLEI 429
            :::...:|:
  Fly   504 IVLQILIEM 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	124/433 (29%)
		Na_Ca_ex	62..199	CDD:279963	55/140 (39%)
		Na_Ca_ex	276..424	CDD:279963	48/153 (31%)
CG17167	NP_001015257.2	TIGR00367	85..503	CDD:273039	123/433 (28%)
		Na_Ca_ex	86..229	CDD:279963	56/144 (39%)
		Na_Ca_ex	356..509	CDD:279963	48/155 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444751
Domainoid	1	1.000	70	1.000	Domainoid score	I3391
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I1830
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	1	1.000	-	-		otm46991
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900