Protein Alignment CG12061 and SLC24A2

DIOPT Version :9

• Sequence 1: NP_001104467.2
• Gene: CG12061 / 3354990
• FlyBaseID: FBgn0040031
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001362779.1
• Gene: SLC24A2 / 25769
• HGNCID: 10976
• Length: 661
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 149/546 - (27%)
• Similarity: 249/546 - (45%)
• Gaps: 152/546 - (27%)

  Fly    33 DARNCTLPAIVEFPNLM-----RQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRM 92
            ::.|.|..|..::|..:     |:|.  ||::..:..:|:|:.||||||::.||::..:...|.:
Human   108 ESENSTDHAQGDYPKDIFSLEERRKG--AIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGI 170

  Fly    93 TYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTQP-TKLDW 156
            :.|||||||:||..||||||.:.:|.|:.:.::|:||||||:|||||.:.|:|.:|::. ..|.|
Human   171 SDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTW 235

  Fly   157 WPVTRDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLSFDRRIQ------------- 208
            ||:.||.::|::.:..|.....|:::||:|:..||..|..||:.:.|:.:::
Human   236 WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV 300

  Fly   209 ---------------------------------------NLVRHE------HAESELLDE----- 223
                                                   :|:|:.      |....|.:|
Human   301 KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYG 365

  Fly   224 -----DPMTR----------------------EEEPLKGFRDHV--------------------C 241
                 |.||.                      |.|...|..:||                    .
Human   366 KLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTPSSDA 430

  Fly   242 AKPKTEYNF-------------------YQWTW---------WAIKYPAELMLACTV-----PSA 273
            ::|....|.                   ....|         :.|.:|....|..|:     ||:
Human   431 SEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSS 495

  Fly   274 RSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGY 338
            |..|.::...:|.||::.|||:.|:...:|..:.|.:.|||||:||||||:|::.:|.||::||.
Human   496 RKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL 560

  Fly   339 GSMAICNAIGSNTFDILVCLGLPWLLKILIYQ-QKIDIDSTALTITTAMLVVTAAVLYLGLLARR 402
            |.||:.:::|||.|||.|.|.|||||..:|:: |.:.:.|..|.....:|.:....:.|.:...:
Human   561 GDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCK 625

  Fly   403 FVMGKTVGYLSIIFYALFLIIACTLE 428
            :.|.|.:|::....|.:||:::..||
Human   626 WRMNKILGFIMFGLYFVFLVVSVLLE 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	138/505 (27%)
		Na_Ca_ex	62..199	CDD:279963	59/137 (43%)
		Na_Ca_ex	276..424	CDD:279963	55/148 (37%)
SLC24A2	NP_001362779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..120		3/11 (27%)
		2A1904	<115..661	CDD:273344	147/539 (27%)
		Alpha-1	174..214		23/39 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..336		0/29 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..439		6/41 (15%)
		Alpha-2	541..572		15/30 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820