Protein Alignment CG12061 and Slc24a1

DIOPT Version :9

• Sequence 1: NP_001104467.2
• Gene: CG12061 / 3354990
• FlyBaseID: FBgn0040031
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_659062.1
• Gene: Slc24a1 / 214111
• MGIID: 2384871
• Length: 1130
• Species: Mus musculus
• Alignment Length: 714
• Identity: 149/714 - (20%)
• Similarity: 246/714 - (34%)
• Gaps: 333/714 - (46%)

  Fly    46 PNLM----RQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRMTYDVAGATFLAAST 106
            |:|.    |::.|:.:.:..:  ||:||.||||||:|.|||:..:.:.|:::.|||||||:||..
Mouse   409 PDLFSVEDRRQGWVVLHIFGM--MYVFVALAIVCDEYFVPALGVITHKLQISEDVAGATFMAAGG 471

  Fly   107 SAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTQP-TKLDWWPVTRDTAWYLIAI 170
            ||||||.:.:|.|:::.::|:||||||:|||||.:.|.|.:|::. ..|.|||:.||.::|::.:
Mouse   472 SAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDL 536

  Fly   171 ASLTYVLWDSLVMWYEAFALLLLYISYVIQLSFDRRIQNLVRHEHA------------------- 216
            :.|.....||.:.|:|:..|||.|..||..:.::::|:..|:.:.:
Mouse   537 SMLIVFFLDSFIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSKPSED 601

  Fly   217 ---ESELLDE-----------------------------------DPMTR--------------- 228
               |:|..|.                                   ||:..
Mouse   602 AVEENEQQDSKKLKLPSVLTRGSSSASLHNSIIRNTIYHLMLHSLDPLGEARPSKDKQESLNQEA 666

  Fly   229 -------------EEEP---------------LKGFR--DHVC---------------------- 241
                         |:||               .||.:  |..|
Mouse   667 RVLSQTKAESSPDEDEPAELPAVTVTPAPAPDAKGDQEDDPGCQEDVDEAERRGEMTGEEGEKET 731

  Fly   242 ----------------------------------------------------------------- 241
                                                                             
Mouse   732 ETEGKKDEQEGETEAERKEDEQEEETEAEGKEQEGETEAEGKEDEQEGETEAEGKKDEQEGETEA 796

  Fly   242 ----------------------------------------------------------------- 241
                                                                             
Mouse   797 EGKEEQEGETEAEGKEDEQEGETEAEGKEEQEGETEAESKEVEQERETEAEGKDKHEGQGETQPD 861

  Fly   242 ------AKPKTEYN--------------------------------------------------- 249
                  .:.:||.|
Mouse   862 DTEVKDGEGETEANAEDQCEATQGEKGADGGGESDGGDSEEEEDEEDEEEEEEEDEEEEEEENEE 926

  Fly   250 --FYQW-------TWWAIKYPAELMLACTVP-----SARSIFFLSMISAILWISLISYLLTWFLT 300
              ..:|       ..:....|....|..|:|     .:|..|.::.:.:|:||::.|||:.|:..
Mouse   927 PLSLEWPDSRQKQAIYLFLLPIVFPLWLTIPDVRRQESRKFFVITFLGSIIWIAMFSYLMVWWAH 991

  Fly   301 ILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLK 365
            .:|..:.|.:.|||||:||||||:|::.:|.||::||.|.||:.:::|||.|||.|.|.:||||.
Mouse   992 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLF 1056

  Fly   366 ILIYQ-QKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYLSIIFYALFLIIACTLE 428
            .||.. |.:.:.|..|.....:|.:....:...:.:.::.|.|.:|:...:.|.:||:|:..||
Mouse  1057 SLINALQPVPVSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLE 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	141/687 (21%)
		Na_Ca_ex	62..199	CDD:279963	64/137 (47%)
		Na_Ca_ex	276..424	CDD:279963	54/148 (36%)
Slc24a1	NP_659062.1	2A1904	1..1130	CDD:273344	149/714 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820