Protein Alignment CG12061 and SLC24A4

DIOPT Version :9

• Sequence 1: NP_001104467.2
• Gene: CG12061 / 3354990
• FlyBaseID: FBgn0040031
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_011534738.1
• Gene: SLC24A4 / 123041
• HGNCID: 10978
• Length: 669
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 168/540 - (31%)
• Similarity: 264/540 - (48%)
• Gaps: 152/540 - (28%)

  Fly    34 ARNCTLPAIVEFP-----NLMRQKSWIAIVVSTLVSMYLFVILAIVCDDYLVPAMERLCYTLRMT 93
            |:|||.|||.|||     |..||..  |:::..|.::|:|..|||||||:.||::|::|..|.::
Human   121 AKNCTDPAIHEFPTDLFSNKERQHG--AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLS 183

  Fly    94 YDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFT-QPTKLDWW 157
            .|||||||:||.:|.||||.:.:|.|:|:||:|:||||||:|||||.|.||||:|. |..:|.||
Human   184 EDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWW 248

  Fly   158 PVTRDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLSFDRRI--------------- 207
            .|.||:.:|.|::..|...::|..::|:|...|::||:.|::.:.::.::
Human   249 AVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGN 313

  Fly   208 ----------------------------------------------------------------- 207
                                                                             
Human   314 PVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMIT 378

  Fly   208 --------------------QNLV--------------RHEHAESELL----DEDPMTREE---- 230
                                |.|:              |||:.|:..:    .|||...:|
Human   379 NKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPP 443

  Fly   231 --------EPLKGFRDHVCAKPKTEYNFYQW--TWWAIKYPAELMLACTVPSA-----RSIFFLS 280
                    ||::.......:.|:...:..:|  ||     |...:|..|:|:.     ...|.::
Human   444 PQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTW-----PLIFLLCVTIPNCSKPRWEKFFMVT 503

  Fly   281 MISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICN 345
            .|:|.|||::.||::.|.:||:||.|.|||.|||:|.||||||||:..:|.||:::|.|.||:.|
Human   504 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSN 568

  Fly   346 AIGSNTFDILVCLGLPWLLKILI--YQQKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKT 408
            .||||.|||||.||:||.|:.::  |...:.|:|..|..:..:|:.:.|:..||:...::.:.:.
Human   569 TIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 633

  Fly   409 VGYLSIIFYALFLIIACTLE 428
            :|...::.||:||..:..:|
Human   634 LGVYVLVLYAIFLCFSIMIE 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12061	NP_001104467.2	TIGR00367	61..422	CDD:273039	152/500 (30%)
		Na_Ca_ex	62..199	CDD:279963	69/137 (50%)
		Na_Ca_ex	276..424	CDD:279963	64/149 (43%)
SLC24A4	XP_011534738.1	TIGR00367	149..645	CDD:273039	151/500 (30%)
		Na_Ca_ex	150..292	CDD:279963	69/141 (49%)
		Na_Ca_ex	499..651	CDD:279963	64/151 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850